A simple and reliable preparative high-performance liquid chromatographic technique for isolation of a bioactive flavone diglycoside from and extract of Cuminum cyminum seeds

Czasopismo : Acta Chromatographica
Tytuł artykułu : A simple and reliable preparative high-performance liquid chromatographic technique for isolation of a bioactive flavone diglycoside from and extract of Cuminum cyminum seeds

Autorzy :
Komsta, Ł.
Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland, lukasz.komsta@am.lublin.pl,
Zięba, A.
The Medical University of Silesia Department of Organic Chemistry ul. Jagiellońska 4 41-200 Sosnowiec Poland, zieba@edu.sum.pl,
Prus, W.
he University of Bielsko-Biała Institute of Environmental Protection and Engineering ul. Willowa 2 43-309 Bielsko-Biała Poland,
Pacenti, M.
University of Florence Occupational Health Division, Department of Public Health Viale Morgagni 48 50100 Florence Italy,
Dugheri, S.
University of Florence Occupational Health Division, Department of Public Health Viale Morgagni 48 50100 Florence Italy,
Gagliano-Candela, R.
University of Bari Forensic Toxicology Division, Department of Internal Medicine and Public Health P.zza G. Cesare 11 70124 Bari Italy,
Strisciullo, G.
University of Bari Forensic Toxicology Division, Department of Internal Medicine and Public Health P.zza G. Cesare 11 70124 Bari Italy,
Franchi, E.
University of Florence Organic Chemistry Department/ProtEra Srl (Spin Off of Magnetic Resonance Center) Via Lastruccia 13 50019 Sesto Fiorentino, Florence Italy,
Degli Esposti, F.
Chromline Srl Via Anita Garibaldi 40 59100 Prato Italy,
Perchiazzi, N.
Chromline Srl Via Anita Garibaldi 40 59100 Prato Italy,
Boccalon, P.
University of Florence Occupational Health Division, Department of Public Health Viale Morgagni 48 50100 Florence Italy,
Arcangeli, G.
University of Florence Occupational Health Division, Department of Public Health Viale Morgagni 48 50100 Florence Italy,
Cupelli, V.
University of Florence Occupational Health Division, Department of Public Health Viale Morgagni 48 50100 Florence Italy,
Szőke, É.
Semmelweis University Department of Pharmacognosy Budapest Hungary,
Petroianu, G.
Florida International University Department of Cell Biology Miami FL USA,
Tekes, K.
Semmelweis University Department of Pharmacodynamics Nagyvárad tér 4 1089 Budapest Hungary, drtekes@gmail.com,
Benkő, B.
Division of Pharmacology and Drug Safety Richter Gedeon Rt. Budapest Hungary,
Szegi, P.
Semmelweis University Department of Pharmacodynamics Nagyvárad tér 4 1089 Budapest Hungary,
Laufer, R.
Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary,
Veress, G.
State Cardiology Hospital Balatonfüred Hungary,
Kuśmierek, K.
Military University of Technology Institute of Chemistry 2 Kaliskiego Str. 00-908 Warsaw Poland,
Bald, E.
University of Lodz Department of Environmental Chemistry 163 Pomorska Str. 90-236 Lodz Poland, ebald@uni.lodz.pl,
Ravi, S.
University of Science Malaysia School of Pharmaceutical Sciences 11800 Pulau Penang Malaysia ravigdk2002@yahoo.co.uk, ravigdk2002@yahoo.co.uk,
Darwis, Y.
University of Science Malaysia School of Pharmaceutical Sciences 11800 Pulau Penang Malaysia ravigdk2002@yahoo.co.uk,
Ravanić, N.
University of Belgrade Faculty of Pharmacy Serbia Yugoslavia,
Filipić, S.
University of Belgrade Faculty of Pharmacy Serbia Yugoslavia,
Nikolić, K.
University of Belgrade Faculty of Pharmacy Serbia Yugoslavia,
Popović, G.
University of Belgrade Faculty of Pharmacy Serbia Yugoslavia,
Vovk, I.
National Institute of Chemistry Laboratory for Food Chemistry Ljubljana Slovenia,
Simonovska, B.
National Institute of Chemistry Laboratory for Food Chemistry Ljubljana Slovenia,
Agbaba, D.
University of Belgrade Faculty of Pharmacy Serbia Yugoslavia, danica@pharmacy.bg.ac.yu,
Rout, K. K.
Utkal University Pharmacognosy and Phytochemistry Division, University Department of Pharmaceutical Sciences Bhubaneswar 751004 Orissa India, kd_rout@yahoo.co.in,
Mishra, S. K.
Utkal University Pharmacognosy and Phytochemistry Division, University Department of Pharmaceutical Sciences Bhubaneswar 751004 Orissa India,
Sherma, J.
Lafayette College Department of Chemistry Easton PA 18042-1782 USA,
Sajewicz, M.
University of Silesia Institute of Chemistry 9 Szkolna Street Katowice Poland,
Rzepa, J.
University of Silesia Institute of Chemistry 9 Szkolna Street Katowice Poland,
Hajnos, M.
Medical University of Lublin Department of Pharmacognosy 1 Chodźki Street 20-093 Lublin Poland, monika.hajnos@am.lublin.pl,
Wojtal, Ł.
University of Silesia Institute of Chemistry 9 Szkolna Street Katowice Poland,
Staszek, D.
University of Silesia Institute of Chemistry 9 Szkolna Street Katowice Poland,
Kowalska, T.
University of Silesia Institute of Chemistry 9 Szkolna Street Katowice Poland,
Waksmundzka-Hajnos, M.
Medical University of Lublin Department of Inorganic Chemistry 6 Staszica Street 20-081 Lublin Poland,
Dávid, Á. Z.
Semmelweis University Department of Pharmaceutics Hőgyes Endre Street 7 1092 Budapest Hungary, dadam@gyok.sote.hu,
Mincsovics, E.
OPLC-NIT Ltd Andor Street 60 1119 Budapest Hungary,
Pápai, K.
Semmelweis University Department of Pharmaceutics Hőgyes Endre Street 7 1092 Budapest Hungary,
Ludányi, K.
Semmelweis University Department of Pharmaceutics Hőgyes Endre Street 7 1092 Budapest Hungary,
Antal, I.
Semmelweis University Department of Pharmaceutics Hőgyes Endre Street 7 1092 Budapest Hungary,
Klebovich, I.
Semmelweis University Department of Pharmaceutics Hőgyes Endre Street 7 1092 Budapest Hungary,
Tang, D.
Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance Nanjing Jiangsu 210009 China,
Yin, Y.
Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China,
Zhang, Z.
Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance Nanjing Jiangsu 210009 China,
Gao, Y.
Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China,
Wei, Y.
Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China,
Chen, Y.
Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China,
Han, Y.
Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China,
Satti, N. K.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India, nksatti@rediffmail.com,
Amina, M.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Dutt, P.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Sharma, V. K.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Sharma, P.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Khan, I.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Gupta, B. D.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Suri, K. A.
Indian Institute of Integrative Medicine (CSIR) Natural Products Chemistry Division Canal Road Jammu Tawi 180001 India,
Sharma, S. C.
Indian Institute of Integrative Medicine (CSIR) Pharmacology Division Canal Road Jammu Tawi 180001 India,
Johri, R. K.
Indian Institute of Integrative Medicine (CSIR) Pharmacology Division Canal Road Jammu Tawi 180001 India,
Sharma, S. N.
Indian Institute of Integrative Medicine (CSIR) Plant Survey Division Canal Road Jammu Tawi 180001 India,
Abstrakty : In this paper we describe a sensitive and reproducible reversed-phase high-performance liquid chromatography (HPLC) method with photodiode-array detection for isolation and quantification of the bioactive hydrophilic constituent 7-(1- O -β-D -galacturonide-4′-(1- O -β-D -glucopyranosyl)-3′,4′,5,7-tetrahydroxyflavone, 1 , from the seeds of Cuminum cyminum . Compound 1 was separated isocratically on a C 18 preparative column, in high purity, after removal of solvents. The purity and identity of the compound were established by use of LC-mass spectrometry and by spectroscopic techniques ( 1 H and 13 C NMR). The purity of 1 was also confirmed by HPTLC.

Słowa kluczowe : Cuminum cyminum seeds, flavones diglycoside, Prep. HPLC, PDA, HPTLC, LCMS,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2009
Numer : Vol. 21, no. 3
Strony : 499 – 512
Bibliografia : 1 G. Charalambous, Spices, Herbs and Edible Fungi, Elsevier, Amsterdam, 1994
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DOI :
Cytuj : Komsta, Ł. ,Zięba, A. ,Prus, W. ,Pacenti, M. ,Dugheri, S. ,Gagliano-Candela, R. ,Strisciullo, G. ,Franchi, E. ,Degli Esposti, F. ,Perchiazzi, N. ,Boccalon, P. ,Arcangeli, G. ,Cupelli, V. ,Szőke, É. ,Petroianu, G. ,Tekes, K. ,Benkő, B. ,Szegi, P. ,Laufer, R. ,Veress, G. ,Kuśmierek, K. ,Bald, E. ,Ravi, S. ,Darwis, Y. ,Ravanić, N. ,Filipić, S. ,Nikolić, K. ,Popović, G. ,Vovk, I. ,Simonovska, B. ,Agbaba, D. ,Rout, K. K. ,Mishra, S. K. ,Sherma, J. ,Sajewicz, M. ,Rzepa, J. ,Hajnos, M. ,Wojtal, Ł. ,Staszek, D. ,Kowalska, T. ,Waksmundzka-Hajnos, M. ,Dávid, Á. Z. ,Mincsovics, E. ,Pápai, K. ,Ludányi, K. ,Antal, I. ,Klebovich, I. ,Tang, D. ,Yin, Y. ,Zhang, Z. ,Gao, Y. ,Wei, Y. ,Chen, Y. ,Han, Y. ,Satti, N. K. ,Amina, M. ,Dutt, P. ,Sharma, V. K. ,Sharma, P. ,Khan, I. ,Gupta, B. D. ,Suri, K. A. ,Sharma, S. C. ,Johri, R. K. ,Sharma, S. N. , A simple and reliable preparative high-performance liquid chromatographic technique for isolation of a bioactive flavone diglycoside from and extract of Cuminum cyminum seeds. Acta Chromatographica Vol. 21, no. 3/2009
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