Journal : Acta Chromatographica
Article : Acer tataricum L. seeds – a new convenient source of gamma-linolenic acid

Authors :
Sherma, J.
Department of Chemistry, Lafayette College, Easton, PA 18042, USA,
Vrchotová, N.
Institute of Systems Biology and Ecology AS CR, Branišovská 31, 370 05 České Budějovice, Czech Republic,
Sivakumar, T.
Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalainagar, Tamil Nadu-608 002, India,
Petruczynik, A.
Department of Inorganic Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland,
Benkő, B.
PhD School of Semmelweis University, 1085 Budapest, Üllői út 26, Hungary, Division of Pharmacology and Drug Safety, Richter Gedeon Rt., Gyömrői út 21, 1475 Budapest, P.O. Box 27, Hungary, Department of Chemistry and Biochemistry, University of Pécs, Péc,
Mori, M.
Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, 376-8515, Japan,
Solangi, A. R.
National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan,
Idris, A. M.
Department of Chemistry, College of Science, King Faisal University, Hofuf 31982, Saudi Arabia,
Milán-Segovia, R.
Laboratorio de Farmacia, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Ave. Manuel Nava No. 6, 78290 San Luis Potosí, S.L.P., Mexico,
Qutab, S. S.
Schazoo Laboratories (Pvt) Ltd, 45 G.T. Road, Lahore-54000, Pakistan,
Agil, M.
Faculty of Pharmacy, Hamdard University New Delhi, 110 062, India,
Dhaneshwar, S. S.
Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune-411 038, India,
Gannu, R.
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India,
Popović, G.
Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, P.O. Box 146, 11000 Belgrade, Serbia,
Mhaske, D. V.
Department of Quality Assurance Techniques and Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Centre for Advanced Pharmaceutical Research, Erandwane, Pune 411038, Maharashtra State, India,
Mohammad, A.
Analytical Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh 202002, India,
Jain, G. K.
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India,
Dembitsky, V. M.
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, The Hebrew University of Jerusalem, Jerusalem 91120, Israel,
Qiao, C. F.
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China,
Waksmundzka-Hajnos, M.
Department of Inorganic Chemistry, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland,
Codreanu, M. V.
Department of Pharmaceutical Botany, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest, 70139, Romania,
Abstract : This research was motivated by the therapeutic benefits of gamma-linolenic acid, a polyunsaturated fatty acid with limited occurrence in plants. Seeds of the tatarian maple (Acer tataricum L.) a widespread member of the natural Romanian flora, were analysed in a search for a new, convenient source of gamma-linolenic acid. Physicochemical study of the fatty oil obtained from the seeds established the fatty oil seed content (gravimetric method), refractive index, relative density, acidity, iodine and saponification values (official methods), and the fatty acid and phytosterol profiles (GC–MS). Tatarian maple seeds were found to contain an important amount of fatty oil (14.28–15.50%) with a high level of unsaturated fatty acids (93.89%). The essential fatty acids identified in this oil were linoleic (34.87%), gamma-linolenic (6.01%), and alpha-linolenic acids (1.04%). Stigmasterol (1.65%), beta-sitosterol (1.15%), and squalene (0.20%) were also identified. Because the not very large amount of gamma-linolenic acid in the seed oil is balanced by the natural abundance of the plant, the seeds of Acer tataricum could be regarded as a new convenient alternative source of this rare and valuable compound.

Keywords :
Publishing house : University of Silesia in Katowice
Publication date : 2007
Number : No. 19
Page : 238 – 245

: 1 U.N. Das, Biotechnol. J., 1, 420 (2006)
2 Y.Y. Fan and R.S. Chapkin, J. Nutr., 128, 1411 (1998)
3 Y. Suresh and U.N. Das, Prostaglandins Leukot. Essent. Fatty Acids, 74, 199 (2006)
4 A.I. Vinik, T.S. Park, K.B. Stansberry, and G.L. Pittenger, Diabetologia, 43, 957 (2000)
5 D.F. Horrobin, Agents Actions Suppl., 37, 120 (1992)
6 S. Barabino, M. Rolando, P. Camicione, G. Ravera, S. Zanardi, S. Giuffrida, and G. Calabria, Cornea, 22, 97 (2003)
7 P. Risé, S. Ghezzi, M.G. Levati, R. Mirtini, C. Colombo, and C. Galli, Lipids, 38, 841 (2003)
8 L. Wang, A.R. Folsom, and J.H. Eckfeldt, Nutr. Metab. Cardiovasc. Dis., 13, 256 (2003)
9 A. Jula, J. Marniemi, T. Rönnemaa, A. Virtanen, and R. Huupponen, Arterioscler. Thromb. Vasc. Biol., 25, 1952 (2005)
10 R.L. Tahvonen, U.S. Schwab, K.M. Linderborg, H.M. Mykkänen, and H.P. Kallio, J. Nutr. Biochem., 16, 353 (2005)
11 M. Guivernau, N. Meza, P. Barja, and O. Roman, Prostaglandins Leukot. Essent. Fatty Acids, 51, 311 (1994)
12 M. Worm, Curr. Opin. Investig. Drugs, 3, 1596 (2002)
13 C.L. Van Gool, M.P. Zeegers, and C. Thijs, Br. J. Dermatol., 150, 728 (2004)
14 P.H. Remans, J.K. Sont, L.W. Wagenaar, W. Wouters-Wesseling, W.M. Zuijderduin, A. Jongma, F.C. Breedveld, and J.M. Van Laar, Eur. J. Clin. Nutr., 58, 839 (2004)
15 B.M. Henz, S. Jablonska, P.C. van de Kerkhof, G. Stingl, M. Blaszczyk, P.G. Vandervalk, R. Veenhuizen, R. Muggli, and D. Raederstorff, Br. J. Dermatol., 40, 685 (1999)
16 L.J. Leventhal, E.G. Boyce, and R.B. Zurier, Ann. Intern. Med., 119, 867 (1993)
17 A. Bakshi, D. Mukherjee, A.K. Banerji, and U.N. Das, Nutrition, 19, 305 (2003)
18 X. Kong, H. Ge, L. Hou, L. Shi, and Z. Liu, Chem. Biol. Interact., 162, 140 (2006)
19 D.E. Barre, Ann. Nutr. Metab., 45, 47 (2001)
20 G. Lotti, C. Paradossi, and F. Marchini, Riv. Soc. Ital. Sci. Aliment., 14, 263 (1985)
21 J. Bruneton, Pharmacognosy, Phytochemistry, Medicinal Plants, Lavoisier Publishing, London, 1995, pp. 26–27
22 European Pharmacopoeia, 5th edn, Council of Europe, Strasbourg, 2005, pp. 110–129
23 W.W. Christie, Gas Chromatography and Lipids. A Practical Guide, The Oily Press, Ayr, Scotland, 1989. pp. 212–215
Qute : Sherma, J. ,Vrchotová, N. ,Sivakumar, T. ,Petruczynik, A. ,Benkő, B. ,Mori, M. ,Solangi, A. R. ,Idris, A. M. ,Milán-Segovia, R. ,Qutab, S. S. ,Agil, M. ,Dhaneshwar, S. S. ,Gannu, R. ,Popović, G. ,Mhaske, D. V. ,Mohammad, A. ,Jain, G. K. ,Dembitsky, V. M. ,Qiao, C. F. ,Waksmundzka-Hajnos, M. ,Codreanu, M. V. ,Codreanu, M. V. , Acer tataricum L. seeds – a new convenient source of gamma-linolenic acid. Acta Chromatographica No. 19/2007