Chemical components and antidiabetic activity of essential oils obtained by hydrodistillation and three solvent extraction methods from Carthamus tinctorius L.

Czasopismo : Acta Chromatographica
Tytuł artykułu : Chemical components and antidiabetic activity of essential oils obtained by hydrodistillation and three solvent extraction methods from Carthamus tinctorius L.

Autorzy :
Xu, L. N.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Gai, F. Y.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Mu, G. F.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Gao, Y.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Liu, C. J.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Luan, F.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Mori, M.
Gunma University Department of Chemistry and Chemical Biology, Graduate School of Engineering 1-5-1 Tenjin-cho Kiryu 376-8515 Japan,
Ikeda, T.
Gunma University Department of Chemistry and Chemical Biology, Graduate School of Engineering 1-5-1 Tenjin-cho Kiryu 376-8515 Japan,
Itabashi, H.
Gunma University Department of Chemistry and Chemical Biology, Graduate School of Engineering 1-5-1 Tenjin-cho Kiryu 376-8515 Japan,
Soomro, R.
University of Sindh National Center of Excellence in Analytical Chemistry Jamshoro Pakistan,
Memon, S. Q.
University of Sindh Institute of Advance Research in Chemical Sciences Jamshoro Pakistan,
Ahmed, M. J.
University of Chittagong Laboratory of Analytical Chemistry, Department of Chemistry Chittagong 4331 Bangladesh,
Memon, N.
University of Sindh National Center of Excellence in Analytical Chemistry Jamshoro Pakistan, najmamemon@gmail.com,
Mallah, A.
University of Sindh M.A. Kazi Institute of Chemistry Jamshoro Pakistan,
Ravi, P. R.
BITS-Pilani Hyderabad Campus Pharmacy Department Ranga Reddy (Dist.) Jawaharnagar Andhra Pradesh India, rahulvats1983@gmail.com,
Aditya, N.
BITS-Pilani Hyderabad Campus Pharmacy Department Ranga Reddy (Dist.) Jawaharnagar Andhra Pradesh India, adityamurthy1212@gmail.com,
Vats, R.
BITS-Pilani Hyderabad Campus Pharmacy Department Ranga Reddy (Dist.) Jawaharnagar Andhra Pradesh India, rpunnarao@gmail.com,
Navaneethan, G.
Sona College of Technology (Anna University) Department of Sciences Salem 636 005 India,
Karunakaran, K.
Sona College of Technology (Anna University) Department of Sciences Salem 636 005 India, drkk@sonatech.ac.in,
Elango, K. P.
Gandhigram Rural Institute (Deemed University) Department of Chemistry Gandhigram 624 302 India,
Prichodko, A.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania,
Janenaite, E.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania,
Smitiene, V.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania,
Vickackaite, V.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania, vida.vickackaite@chf.vu.lt,
Akhtar, N.
Hamdard University Department of Pharmaceutics, Faculty of Pharmacy New Delhi 110062 India,
Faiyazuddin, M.
Hamdard University Department of Pharmaceutics, Faculty of Pharmacy New Delhi 110062 India, md.faiyazuddin@yahoo.co.in,
Mustafa, G.
Hamdard University Department of Pharmaceutics, Faculty of Pharmacy New Delhi 110062 India,
Sultana, Y.
Hamdard University Department of Pharmaceutics, Faculty of Pharmacy New Delhi 110062 India,
Baboota, S.
Hamdard University Department of Pharmaceutics, Faculty of Pharmacy New Delhi 110062 India,
Ali, J.
Hamdard University Department of Pharmaceutics, Faculty of Pharmacy New Delhi 110062 India,
Wang, D.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China,
Bai, A.
inan Municipal Center For Disease Control and Prevention Jinan 250001 P. R. China,
Lin, X.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China,
Fang, L.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China,
Shu, X.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China,
Shi, X.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China,
Sun, Q.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China,
Wang, X.
Shandong Academy of Sciences Shandong Analysis and Test Center 19 Keyuan Street Jinan 250014 P. R. China, wxjn1998@126.com,
Wu, J.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Xing, H.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Tang, D.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China, tdq993@hotmail.com,
Gao, Y.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Yin, X.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Du, Q.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Jiang, X.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Yang, D.
Xuzhou Medical College Key Laboratory of New Drug and Clinical Application Xuzhou Jiangsu 221004 China,
Lu, W.
Xi’an Jiao tong University School of Medicine Xi’an 710061 P. R. China,
Yang, F.
Xi’an Jiao tong University School of Medicine Xi’an 710061 P. R. China,
Wang, S.
Xi’an Jiao tong University School of Medicine Xi’an 710061 P. R. China, wangsc@mail.xjtu.edu.cn,
Li, L.
Chinese Academy of Sciences Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry Urumqi 830011 China,
Wang, Q.
Chinese Academy of Sciences Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry Urumqi 830011 China,
Yang, Y.
Chinese Academy of Sciences Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry Urumqi 830011 China,
Wu, G.
Xinjiang Medical University School of Pharmacy Urumqi 830054 China,
Xin, X.
Chinese Academy of Sciences Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry Urumqi 830011 China,
Aisa, H. A.
Chinese Academy of Sciences Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry Urumqi 830011 China, haji@ms.xjb.ac.cn,
Abstrakty : The chemical compositions of essential oils extracted by n-hexane extract (HE), petroleum ether extract (PE), dichloromethane extract (DE), and hydrodistillation (HD) from Carthamus tinctorius L. (safflower) were analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 86 compounds from four different extracts were identified, and the contents were 97.65%, 98.05%, 98.93%, and 99.68%, respectively. 6,10,14-Trimethyl-2-pentadecanone, hexadecanoic acid, methyl ester, hexadecanoic acid, 8,11-octadecadienoic acid, methyl ester, and 9,12,15-octadecatrien-1-ol were the major constituents of the extracts. The antidiabete activity was assayed in vitro by against protein tyrosine phosphatase 1B (PTP1B). The results showed that the HE exhibited the best in vitro inhibitory enzyme activity against PTP1B, which holds a good potential for treating diabetes and obesity.

Słowa kluczowe : Carthamus tinctorius L. (safflower), essential oils, hydrodistillation, solvent extract, GC-MS, antidiabete activity,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2012
Numer : Vol. 24, no. 4
Strony : 653 – 665
Bibliografia : 1 T.A. Suleimanov., Chem. Nat. Compd., 40, 13 (2004)
2 L. Fan, H. Zhao, M. Xu, L. Zhou, H. Guo, J. Han, B. Wang, and D. Guo, J. Chromatogr. A, 1216, 2063 (2009)
3 National Traditional Herbal Drugs Collection, People’s Medical Publishing House, Beijing, 1975, pp. 386
4 Q.R. Nie, Lishizhen Med. Mater. Med. Res., 14, 503 (2003)
5 F. Liu, Y. Wei, and X. Yang, Acta Pharm. Sin., 27, 785 (1992)
6 H.L. Zhang, A. Nagatsu, T. Watanabe, J. Sakakibara, and H. Okuyama, Chem. Pharm. Bull, 45, 1910 (1997)
7 H. Zhu, Z. Wang, C. Ma, J. Tian, F. Fu, C. Li, D. Guo, E. Roder, and K. Liu, Planta Med., 69, 429 (2003)
8 X.H. Jiang and X.M. Huang, Chin. Arch. Tradit. Chin. Med., 28, 832 (2010)
9 J.S. Roh, J.Y. Han, J.H. Kim, and J.K. Hwang, Biol. Pharm. Bull., 27, 1976 (2004)
10 Z. Lu, F. Liu, and J. Hu, Acta Pharmacol. Sin., 12, 537 (1991)
11 A. Izuru, T. Yoshinori, W. Tetsuya, A. Sachiko, M. Kensuke, K. Takao, and N. Kazuo, Int. Immunopharmacol., 2, 1155 (2002)
12 Wei and K. Wu, J. Chin. Med. Mater, 23, 430 (2000)
13 M. Xu, J. Prac. Tradit. Chin. Internal Med., 22, 46 (2008)
14 W. Wu, J. Med. Theor. Prac., 23, 413 (2010)
15 K. Satoru, W. Tsumoru, M. Satoshi, F. Kaori, O. Junichi, and M. Shigeru, 2005, WO2005094858(A1)
16 M.R. Meselhy, S. Kadota, Y. Momose, N. Hatakeyama, A. Kusai, M. Hattori, and T. Namba, Chem. Pharm. Bull, 41, 1796 (1993)
17 G. Zhao, Y. Gai, W. Chu, G. Qin, and L. Guo, Eur. Neuropsychopharm., 19, 749 (2009)
18 X. Xu, Tradit. Chin. Med., 9, 31 (1984)
19 E.H. Allen and C.A. Thomas, Phytochem., 10, 1579 (1971)
20 W. Han, Y. Xing, and T.G. Kang, Chin. Arch. Tradit. Chin. Med., 28, 881 (2010)
21 Nagatsu, H.L. Zhang, T. Watanabe, N. Taniguchi, K. Hatano, H. Mizukami, and J. Sakakibara, Chem. Pharm. Bull., 46, 1044 (1998)
22 Y. Liu, J. Yang, and Q. Liu, Chin. Med. Mat., 28, 288 (2005)
23 X. Zhang, Y. Li, Y. Wang, X. Shi, F. Li, and J. Gui, Chin. J. Exp. Tradit. Med. Form., 16, 19 (2010)
24 Y. Romsicki, B.P. Kennedy, and E. Asante-Appiah, Arch. Biochem. Biophys., 414, 40 (2003)
25 S. Shresth, B.R. Bhattarai, B. Kafle, K.H. Lee, and H. Cho, Bioorg. Med. Chem., 16, 8643 (2008)
26 H. Park, B.R. Bhattarai, S.W. Ham, and H. Cho, Eur. J. Med. Chem., 44, 3280 (2009)
27 S. Burt. Int. J. Food Microbiol., 94, 223 (2004)
28 S. Shresth, B.R. Bhattarai, K.H. Lee, and H. Cho, Bioorg. Med. Chem, 15, 6535 (2007)
29 National Commission of Chinese Pharmacopoeia, Pharmacopoeia of the People’s Republic of China, Beijing, 2005, appendix 57
30 Taghibiglou, F. Rashid-Kolvear, S.C. Van Iderstine, H.L. Tien, I.G. Fantus, G.F. Lewis, and K. Adeli, J. Bio. Chem. 277, 793 (2002)
31 X. Han, R. Zhang, and J. Bi, Chin. Tradit. Patent Med., 31, 212 (2009)
32 Chakraborty, Curr. Protein Pept. Sci, 7, 113 (2006)
33 S. Zhao and G. Fu, Chin. Tradit. Herbal Drugs, 28, 187 (1997)
34 T. Mao and W. Chen, Foreign Medical Sciences (Section of Hygiene), 35, 352 (2008)
35 J.A. Nettleton and R. Katz, J. Am. Diet. Assoc., 105, 428 (2005)
DOI :
Cytuj : Xu, L. N. ,Gai, F. Y. ,Mu, G. F. ,Gao, Y. ,Liu, C. J. ,Luan, F. ,Mori, M. ,Ikeda, T. ,Itabashi, H. ,Soomro, R. ,Memon, S. Q. ,Ahmed, M. J. ,Memon, N. ,Mallah, A. ,Ravi, P. R. ,Aditya, N. ,Vats, R. ,Navaneethan, G. ,Karunakaran, K. ,Elango, K. P. ,Prichodko, A. ,Janenaite, E. ,Smitiene, V. ,Vickackaite, V. ,Akhtar, N. ,Faiyazuddin, M. ,Mustafa, G. ,Sultana, Y. ,Baboota, S. ,Ali, J. ,Wang, D. ,Bai, A. ,Lin, X. ,Fang, L. ,Shu, X. ,Shi, X. ,Sun, Q. ,Wang, X. ,Wu, J. ,Xing, H. ,Tang, D. ,Gao, Y. ,Yin, X. ,Du, Q. ,Jiang, X. ,Yang, D. ,Lu, W. ,Yang, F. ,Wang, S. ,Li, L. ,Wang, Q. ,Yang, Y. ,Wu, G. ,Xin, X. ,Aisa, H. A. , Chemical components and antidiabetic activity of essential oils obtained by hydrodistillation and three solvent extraction methods from Carthamus tinctorius L.. Acta Chromatographica Vol. 24, no. 4/2012
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