Comprehensive profiling of flavonoids in Scutellaria incana L. using LC-Q-TOF-MS

Czasopismo : Acta Chromatographica
Tytuł artykułu : Comprehensive profiling of flavonoids in Scutellaria incana L. using LC-Q-TOF-MS

Autorzy :
Fatemi, M. H.
University of Mazandaran Laboratory of Chemometrics, Faculty of Chemistry Babolsar Iran, mhfatemi@umz.ac.ir,
Elyasi, M.
University of Mazandaran Laboratory of Chemometrics, Faculty of Chemistry Babolsar Iran,
Sowa, I.
Medical University of Lublin Department of Analytical Chemistry Chodźki 4a 20-093 Lublin Poland, i.sowa@umlub.pl,
Zajdel, D.
Medical University of Lublin Department of Analytical Chemistry Chodźki 4a 20-093 Lublin Poland,
Kocjan, R.
Medical University of Lublin Department of Analytical Chemistry Chodźki 4a 20-093 Lublin Poland,
Pizoń, M.
Medical University of Lublin Department of Analytical Chemistry Chodźki 4a 20-093 Lublin Poland,
Wójciak-Kosior, M.
Medical University of Lublin Department of Analytical Chemistry Chodźki 4a 20-093 Lublin Poland,
Hadad, G. M.
Suez Canal University Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Ismailia 41522 Egypt, ghhadad@hotmail.com,
Abdel-Salam, R. A.
Suez Canal University Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Ismailia 41522 Egypt, dr_rasalam@yahoo.com,
Abdel-Hameed, E. A.
Suez Canal University Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Ismailia 41522 Egypt,
Liu, W.-Y.
China Pharmaceutical University Department of Pharmaceutical Analysis 24 Tongjiaxiang Nanjing 210009 China, liuwenyuan8506@163.com,
Xie, S.-L.
China Pharmaceutical University Department of Pharmaceutical Analysis 24 Tongjiaxiang Nanjing 210009 China,
Xu, X. Z.
China Pharmaceutical University Department of Pharmaceutical Analysis 24 Tongjiaxiang Nanjing 210009 China,
Wu, C. Y.
China Pharmaceutical University Department of Pharmaceutical Analysis 24 Tongjiaxiang Nanjing 210009 China,
Feng, F.
China Pharmaceutical University Department of Phytochemistry 24 Tongjiaxiang Nanjing 210009 China,
Maślanka, A.
Jagiellonian University Medical College, Pharmaceutical Faculty, Department of Inorganic and Analytical Chemistry Medyczna 9 30-688 Krakow Poland,
Hubicka, U.
Jagiellonian University Medical College, Pharmaceutical Faculty, Department of Inorganic and Analytical Chemistry Medyczna 9 30-688 Krakow Poland,
Krzek, J.
Jagiellonian University Medical College, Pharmaceutical Faculty, Department of Inorganic and Analytical Chemistry Medyczna 9 30-688 Krakow Poland, jankrzek@cm-uj.krakow.pl,
Walczak, M.
Jagiellonian University Medical College, Pharmaceutical Faculty, Department of Pharmacokinetics and Physical Pharmacy Medyczna 9 30-688 Krakow Poland,
Izworski, G.
Jagiellonian University Medical College, Pharmaceutical Faculty, Department of Inorganic and Analytical Chemistry Medyczna 9 30-688 Krakow Poland,
Suchy, D.
Medical University of Silesia Department of Internal Medicine and Clinical Pharmacology Medyków 18 PL 40752 Katowice Poland, dariuszsuchy@gmail.com,
Łabuzek, K.
Medical University of Silesia Department of Internal Medicine and Clinical Pharmacology Medyków 18 PL 40752 Katowice Poland,
Pierzchała, O.
Medical University of Silesia Department of Internal Medicine and Clinical Pharmacology Medyków 18 PL 40752 Katowice Poland,
Okopień, B.
Medical University of Silesia Department of Internal Medicine and Clinical Pharmacology Medyków 18 PL 40752 Katowice Poland,
Vamsi Krishna, M.
Alliance Institute of Advanced Pharmaceutical and Health Sciences Ameerpet, Hyderabad 500038 Andhra Pradesh India, marothu_vamsi@rediffmail.com,
Dash, R. N.
Alliance Institute of Advanced Pharmaceutical and Health Sciences Ameerpet, Hyderabad 500038 Andhra Pradesh India,
Jalachandra Reddy, B.
Alliance Institute of Advanced Pharmaceutical and Health Sciences Ameerpet, Hyderabad 500038 Andhra Pradesh India,
Venugopal, P.
Alliance Institute of Advanced Pharmaceutical and Health Sciences Ameerpet, Hyderabad 500038 Andhra Pradesh India,
Sandeep, P.
Alliance Institute of Advanced Pharmaceutical and Health Sciences Ameerpet, Hyderabad 500038 Andhra Pradesh India,
Madhavi, G.
Alliance Institute of Advanced Pharmaceutical and Health Sciences Ameerpet, Hyderabad 500038 Andhra Pradesh India,
Raghavi, K.
K.V.S.R Siddhartha College of Pharmaceutical Sciences Vijayawada 520010 AP India,
Sindhura, M.
K.V.S.R Siddhartha College of Pharmaceutical Sciences Vijayawada 520010 AP India,
Prashanthi, R.
K.V.S.R Siddhartha College of Pharmaceutical Sciences Vijayawada 520010 AP India,
Nalluri, B. N.
K.V.S.R Siddhartha College of Pharmaceutical Sciences Vijayawada 520010 AP India, buchinalluri@yahoo.com,
Jain, P. S.
R. C. Patel Institute of Pharmaceutical Education and Research Karwand Naka, Shirpur, Dist. Dhule 425 405 (M. S.) India, pritash79@yahoo.com,
Patel, M. K.
R. C. Patel Institute of Pharmaceutical Education and Research Karwand Naka, Shirpur, Dist. Dhule 425 405 (M. S.) India,
Surana, S. J.
R. C. Patel Institute of Pharmaceutical Education and Research Karwand Naka, Shirpur, Dist. Dhule 425 405 (M. S.) India,
Oniszczuk, A.
Medical University in Lublin Department of Inorganic Chemistry 4A Chodzki Street 20-093 Lublin Poland,
Waksmundzka-Hajnos, M.
Medical University in Lublin Department of Inorganic Chemistry 4A Chodzki Street 20-093 Lublin Poland, monika.hajnos@am.lublin.pl,
Gadzikowska, M.
Medical University in Lublin Department of Inorganic Chemistry 4A Chodzki Street 20-093 Lublin Poland,
Podgórski, R.
Medical University in Lublin Department of Inorganic Chemistry 4A Chodzki Street 20-093 Lublin Poland,
Oniszczuk, T.
University of Life Sciences in Lublin Department of Food Process Engineering Doświadczalna 44 20-236 Lublin Poland,
Nurul Islam, M.
University College Dublin, Belfield School of Biology and Environmental Science Dublin 4 Ireland,
Downey, F.
University College Dublin, Belfield School of Biology and Environmental Science Dublin 4 Ireland,
Ng, C. K.-Y.
carl.ng@ucd.ie,
Abstrakty : Scutellaria L. is a diverse genus of the Lamiaceae (Labiatae) family of over 300 herbaceous plants commonly known as skullcaps. Various species of Scutellaria are used as ethnobotanical herbs for the treatment of ailments like cancer, jaundice, cirrhosis, anxiety, and nervous disorders. Scutellaria incana L., commonly known as the Hoary skullcap, is a traditional medicinal plant used by native Americans as a sedative for nervousness or anxiety. S. incana metabolites were identified by comparing their high-performance liquid chromatography (HPLC) retention times and mass spectra with those of the corresponding authentic standards. Where standards were unavailable, the structures were characterized on the basis of their tandem mass spectrometry (MS/MS) spectra following collision-induced dissociation (CID) and the accurate masses of the corresponding deprotonated molecules [M-H]− (mass accuracy ± 5 ppm). A total of 40 flavonoids, including two phenolic glycosides, were identified from leaves, stems, and roots of S. incana. Differences in the flavonoid composition between leaves, stems, and roots in S. incana were observed although the flavonoid profile of S. incana is consistent with other Scutellaria species. Further work should focus on assessing the potential of S. incana as a source of these bioactive metabolites.

Słowa kluczowe : Scutellaria incana, flavonoids, phenolic glycosides, LC-MS,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2013
Numer : Vol. 25, no. 3
Strony : 555 – 569
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DOI :
Cytuj : Fatemi, M. H. ,Elyasi, M. ,Sowa, I. ,Zajdel, D. ,Kocjan, R. ,Pizoń, M. ,Wójciak-Kosior, M. ,Hadad, G. M. ,Abdel-Salam, R. A. ,Abdel-Hameed, E. A. ,Liu, W.-Y. ,Xie, S.-L. ,Xu, X. Z. ,Wu, C. Y. ,Feng, F. ,Maślanka, A. ,Hubicka, U. ,Krzek, J. ,Walczak, M. ,Izworski, G. ,Suchy, D. ,Łabuzek, K. ,Pierzchała, O. ,Okopień, B. ,Vamsi Krishna, M. ,Dash, R. N. ,Jalachandra Reddy, B. ,Venugopal, P. ,Sandeep, P. ,Madhavi, G. ,Raghavi, K. ,Sindhura, M. ,Prashanthi, R. ,Nalluri, B. N. ,Jain, P. S. ,Patel, M. K. ,Surana, S. J. ,Oniszczuk, A. ,Waksmundzka-Hajnos, M. ,Gadzikowska, M. ,Podgórski, R. ,Oniszczuk, T. ,Nurul Islam, M. ,Downey, F. ,Ng, C. K.-Y. , Comprehensive profiling of flavonoids in Scutellaria incana L. using LC-Q-TOF-MS. Acta Chromatographica Vol. 25, no. 3/2013
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