Journal : Acta Chromatographica
Article : Determination of the lipophilicity of new azaphenothiazines by reversed-phase thin-layer chromatography

Authors :
Komsta, Ł.
Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland, lukasz.komsta@am.lublin.pl,
Zięba, A.
The Medical University of Silesia Department of Organic Chemistry ul. Jagiellońska 4 41-200 Sosnowiec Poland, zieba@edu.sum.pl,
Prus, W.
he University of Bielsko-Biała Institute of Environmental Protection and Engineering ul. Willowa 2 43-309 Bielsko-Biała Poland,
Abstract : The lipophilicity R M0 and log P TLC of thirteen novel, potentially biologically active, 12 H -quino[3,4- b] [1,4] benzothiazinium salts have been determined by reversed-phase thin-layer chromatography using RP-18 silica plates and methanol-aqueous Tris buffer solution mixtures as mobile phases. R M values of the compounds were linearly dependent on methanol concentration; extrapolation of these to 0% methanol gave the lipophilicity R M0 . log P TLC was obtained from R M0 by use of a calibration curve obtained for five standards of known experimental lipophilicity (log P). Lipophilicity log P calcd for the thirteen quinobenzothiazines was calculated by use of nine software products. The values determined were discussed in terms of structure-lipophilicity relationships. The results indicate that chromatographic lipophilicity R M0 can be used as a measure of the lipophilicity of the azaphenothiazine derivatives investigated.

Keywords : lipophilicity, azaphenothiazines, RP-TLC,
Publishing house : University of Silesia in Katowice
Publication date : 2009
Number : Vol. 21, no. 3
Page : 369 – 378

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DOI :
Qute : Komsta, Ł. ,Zięba, A. ,Prus, W. ,Prus, W. , Determination of the lipophilicity of new azaphenothiazines by reversed-phase thin-layer chromatography. Acta Chromatographica Vol. 21, no. 3/2009
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