Development of an UPLC-QTOF-MS method for qualitative and quantitative analysis of Saussurea eopygmaea

Czasopismo : Acta Chromatographica
Tytuł artykułu : Development of an UPLC-QTOF-MS method for qualitative and quantitative analysis of Saussurea eopygmaea

Autorzy :
Petruczynik, A.
Medical University of Lublin Department of Inorganic Chemistry 4a Chodźki Str. 20-093 Lublin Poland, annapetruczynik@poczta.onet.pl,
Waksmundzka-Hajnos, M.
Medical University of Lublin Department of Inorganic Chemistry 4a Chodźki Str. 20-093 Lublin Poland,
Rykowska, I.
Adam Mickiewicz University Faculty of Chemistry Umultowska 89b 61-614 Poznań Poland, obstiwo@amu.edu.pl,
Wasiak, W.
Adam Mickiewicz University Faculty of Chemistry Umultowska 89b 61-614 Poznań Poland,
Inglot, T. W.
Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland,
Gumieniczek, A.
anna.gumieniczek@am.lublin.pl,
Komsta, Ł.
Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland,
Związek, R.
Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland,
Sharaf El Din, M. K.
Mansoura University Department of Analytical Chemistry, Faculty of Pharmacy Mansoura 35516 Egypt,
Ibrahim, F.
Mansoura University Department of Analytical Chemistry, Faculty of Pharmacy Mansoura 35516 Egypt,
Eid, M. I.
Mansoura University Department of Analytical Chemistry, Faculty of Pharmacy Mansoura 35516 Egypt,
Wahba, M. E. K.
Mansoura University Department of Analytical Chemistry, Faculty of Pharmacy Mansoura 35516 Egypt, marywahba2004@yahoo.com,
El-Shaboury, S. R.
Assiut University Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut 71526 Egypt,
Hussein, A. S.
Assiut University Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut 71526 Egypt,
Mohamed, N. A.
Assiut University Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut 71526 Egypt, mohamed_mounir2000@yahoo.com,
El-Sutohy, M. M.
Al-Azhar University, Assiut Branch Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut 71524 Egypt,
Madej, K.
Jagiellonian University Department of Analytical Chemistry, Faculty of Chemistry Ingardena St. 3 30-060 Krakow Poland, madejk@chemia.uj.edu.pl,
Persona, K.
Jagiellonian University Department of Analytical Chemistry, Faculty of Chemistry Ingardena St. 3 30-060 Krakow Poland,
Nizio, M.
Jagiellonian University Department of Analytical Chemistry, Faculty of Chemistry Ingardena St. 3 30-060 Krakow Poland,
Emami, J.
Isfahan University of Medical Sciences Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences Isfahan Iran, emami@pharm.mui.ac.ir,
Rezazadeh, M.
Isfahan University of Medical Sciences Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences Isfahan Iran,
Smolarz, H. D.
Medical University of Lublin Chair and Department of Pharmaceutical Botany Lublin Poland, h.smolarz@am.lublin.pl,
Hałka, A.
Medical University of Lublin Department of Physical Chemistry, Chair of Chemistry Lublin Poland,
Chabros, O.
Medical University of Lublin Chair and Department of Pharmaceutical Botany Lublin Poland,
Dzido, T. H.
Medical University of Lublin Department of Physical Chemistry, Chair of Chemistry Lublin Poland,
Rode, S.
Saraswati Vidya Bhawan’s College of Pharmacy Sonarpada, Dombivli (East) 421 204 Maharashtra India,
Bhujbal, P.
Saraswati Vidya Bhawan’s College of Pharmacy Sonarpada, Dombivli (East) 421 204 Maharashtra India,
Sandhya, P.
Saraswati Vidya Bhawan’s College of Pharmacy Sonarpada, Dombivli (East) 421 204 Maharashtra India, iamsandhyap@yahoo.com,
Zhu, F. X.
Jiangsu Provincial Academy of Chinese Medicine Key Laboratory of New Drug Delivery System of Chinese Meteria Medica No. 100 Shizi Road Nanjing 210028 China,
Jia, X. B.
Jiangsu Provincial Academy of Chinese Medicine Key Laboratory of New Drug Delivery System of Chinese Meteria Medica No. 100 Shizi Road Nanjing 210028 China,
Cai, Y.
Jiangsu Provincial Academy of Chinese Medicine Key Laboratory of New Drug Delivery System of Chinese Meteria Medica No. 100 Shizi Road Nanjing 210028 China,
Chen, Y.
Jiangsu Provincial Academy of Chinese Medicine Key Laboratory of New Drug Delivery System of Chinese Meteria Medica No. 100 Shizi Road Nanjing 210028 China,
Bhope, S. G.
MIDC Ranjangaon Analytical R&D, Tulip Lab Pvt. Ltd. F-20/21 Pune 412220 India, bshrinivas16@gmail.com,
Kuber, V. V.
MIDC Ranjangaon Analytical R&D, Tulip Lab Pvt. Ltd. F-20/21 Pune 412220 India,
Nagore, D. H.
MIDC Ranjangaon Analytical R&D, Tulip Lab Pvt. Ltd. F-20/21 Pune 412220 India,
Gaikwad, P. S.
MIDC Ranjangaon Analytical R&D, Tulip Lab Pvt. Ltd. F-20/21 Pune 412220 India,
Patil, M. J.
Marathwada Mitra Mandal College of Pharmacy Department of Pharmacognosy Pune India,
Liao, Z. X.
Southeast University Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering Nanjing 211189 China,
Zhang, B. B.
Southeast University Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering Nanjing 211189 China,
Ding, L. S.
Chinese Academy of Sciences Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology Chengdu 610041 China,
Zhou, Y.
Chinese Academy of Sciences Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology Chengdu 610041 China, zhouyan@cib.ac.cn,
Abstrakty : An ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry UPLC-QTOF-MS method has been developed for qualitative and quantitative analysis major compounds in Saussurea eopygmaea Hand-Mazz, which has long been used as a traditional Tibetan medicine. This method was validated to be sensitive, precise, and accurate with the limits of detection of compounds 2,3,4,6, and 7 with 0.67–1.90 μg mL-1, the overall intra-day and inter-day variations less than 8.45%, and the overall recovery over 93.8%, respectively. The correlation coefficients (R2) of the calibration curves were higher than 0.998. In addition, by comparison MS and MS/MS spectra with those of authentic compounds and literatures, a total of 14 main peaks were identified within 6 min. These results demonstrate that this approach has the potential for quality control of S. eopygmaea and other Tibetan herbal medicines.

Słowa kluczowe : UPLC, QTOF-MS, Saussurea eopygmaea,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2013
Numer : Vol. 25, no. 1
Strony : 171 – 180
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DOI :
Cytuj : Petruczynik, A. ,Waksmundzka-Hajnos, M. ,Rykowska, I. ,Wasiak, W. ,Inglot, T. W. ,Gumieniczek, A. ,Komsta, Ł. ,Związek, R. ,Sharaf El Din, M. K. ,Ibrahim, F. ,Eid, M. I. ,Wahba, M. E. K. ,El-Shaboury, S. R. ,Hussein, A. S. ,Mohamed, N. A. ,El-Sutohy, M. M. ,Madej, K. ,Persona, K. ,Nizio, M. ,Emami, J. ,Rezazadeh, M. ,Smolarz, H. D. ,Hałka, A. ,Chabros, O. ,Dzido, T. H. ,Rode, S. ,Bhujbal, P. ,Sandhya, P. ,Zhu, F. X. ,Jia, X. B. ,Cai, Y. ,Chen, Y. ,Bhope, S. G. ,Kuber, V. V. ,Nagore, D. H. ,Gaikwad, P. S. ,Patil, M. J. ,Liao, Z. X. ,Zhang, B. B. ,Ding, L. S. ,Zhou, Y. , Development of an UPLC-QTOF-MS method for qualitative and quantitative analysis of Saussurea eopygmaea. Acta Chromatographica Vol. 25, no. 1/2013
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