Establishment and validation of quantitative analysis of multi-components by single-marker for quality assessment of compound danshen preparations

Czasopismo : Acta Chromatographica
Tytuł artykułu : Establishment and validation of quantitative analysis of multi-components by single-marker for quality assessment of compound danshen preparations

Autorzy :
Kuc, J.
Cracow University of Technology Department of Chemical Engineering and Technology, Department of Analytical Chemistry Warszawska 24 31-155 Cracow Poland, jkuc@chemia.pk.edu.pl,
Grochowalski, A.
Cracow University of Technology Department of Chemical Engineering and Technology, Department of Analytical Chemistry Warszawska 24 31-155 Cracow Poland,
Mach, S.
Institute of Public Health Ostrava Centre of Hygienic Laboratories Dobrá 240 739 51 Frýdek-Místek Czech Republic,
Placha, D.
VŠB-Technical University of Ostrava Centrum Nanotechnology 17 Listopadu 15/2172 708 33 Ostrava Czech Republic,
Furusawa, N.
Osaka City University Graduate School of Human Life Science Osaka 558-8585 Japan,
Stoilova, N.
Bulgarian Food Safety Agency Central Laboratory of Veterinary Control and Ecology (CLVCE) 5 “Iskarsko shousse” str., 1528 Sofia Bulgaria, nadqstoilova@abv.bg,
Surleva, A.
University of Chemical Technology and Metallurgy Analytical Chemistry Department 8 “St. Kl. Ohridski” blvd., 1756 Sofia Bulgaria,
Stoev, G.
Bulgarian Food Safety Agency Central Laboratory of Veterinary Control and Ecology (CLVCE) 5 “Iskarsko shousse” str., 1528 Sofia Bulgaria,
Popovic, N.
Lafayette College Department of Chemistry Easton PA USA,
Sherma, J.
Lafayette College Department of Chemistry Easton PA USA, shermaj@lafayette.edu,
Dixit, S.
Yeungnam University Department of Chemistry Gyeongsan 712-749 South Korea, drdixit.shuchi@gmail.com,
Dubey, R.
riturajdubey0@gmail.com,
Bhushan, R.
Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India, rbushfcy@iitr.ernet.in,
Fouad, M. A.
Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini St. Cairo 11562 Egypt, merro911@yahoo.com,
Elkady, E. F.
Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini St. Cairo 11562 Egypt,
Csomor, V.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Laufer, R.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Pöstényi, Z.
Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary,
Kalász, H.
Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary, huba.kalasz@gmail.com,
Adeghate, E.
United Arab Emirates University Department of Anatomy Al Ain UAE,
Nurulain, S. M.
United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain UAE,
Tekes, K.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Adem, A.
United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain UAE,
Kwiecień, A.
Jagiellonian University Medical College, Faculty of Pharmacy Department of Inorganic and Analytical Chemistry 9 Medyczna Street 30-688 Kraków Poland,
Krzek, J.
Jagiellonian University Medical College, Faculty of Pharmacy Department of Inorganic and Analytical Chemistry 9 Medyczna Street 30-688 Kraków Poland, jankrzek@cm-uj.krakow.pl,
Gądek, M.
Jagiellonian University Medical College, Faculty of Pharmacy Department of Inorganic and Analytical Chemistry 9 Medyczna Street 30-688 Kraków Poland,
Kuźma, Ł.
Medical University of Łódź Department of Biology and Pharmaceutical Botany Muszyńskiego 1 st. 90-151 Łódź Poland, lukasz.kuzma@umed.lodz.p,
Wysokińska, H.
Medical University of Łódź Department of Biology and Pharmaceutical Botany Muszyńskiego 1 st. 90-151 Łódź Poland,
Dong, H.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China, hongxingd6@yahoo.com.cn,
Wang, Y.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Ou, Y.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
She, J.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Shen, X.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Li, J.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Zhang, C.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Liu, L.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Xiong, W.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Yan, R. Q.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Liu, Y. N.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Peng, S. W.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Jiang, Z. Z.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Chai, X.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Qi, A. D.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Wang, Y. F.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China, wangyuefei_2006@hotmail.com,
Abstrakty : Compound danshen preparations (CDPs) are used clinically for the treatment of cardiovascular and cerebrovascular diseases. By using the quantitative analysis of multi-components by single-marker (QAMS) method, sixteen compounds (danshensu, protocatechuic acid, protocatechuicaldehyde, caffeic acid, rosmarinic acid, lithospermic acid, notoginsenoside R1, salvianolic acid B, ginsenoside Rg1, ginsenoside Re, salvianolic acid A, salvianolic acid C, ginsenoside Rb1, ginsenoside Rd, cryptotanshinone, and tanshinone IIA were quantified on an ACQUITY ultraperformance liquid chromatography (UPLC) HSS T3 column (2.1 × 100 mm, 1.8 μm) with the mobile phase consisting of 0.1% formic acid aqueous solution (A) and acetonitrile (B) using a gradient elution at the flow rate of 0.30 mL/min in 30 min at 30°C, which was also validated by UPLC-diode array detection (DAD) and UPLC-electrospray ionization multistage/mass spectrometry (ESI-MS/MS) for assuring the feasibility and accuracy. Tested by robustness experiment under slightly changeable conditions, the stability of relative correction factor (RCF) proved to be stable, with RSDs below 5.69%, except for notoginsenoside R1 with relative standard deviation (RSD) 7.83%. This reliable and convenient QAMS method resolved the problem of standard substance insufficiency and improved the quality assessment of preparations consisting of complex compounds with different chemical structures, such as CDPs.

Słowa kluczowe : compound danshen preparation, QAMS, robustness, quantification,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2014
Numer : Vol. 26, no. 4
Strony : 695 – 710
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DOI :
Cytuj : Kuc, J. ,Grochowalski, A. ,Mach, S. ,Placha, D. ,Furusawa, N. ,Stoilova, N. ,Surleva, A. ,Stoev, G. ,Popovic, N. ,Sherma, J. ,Dixit, S. ,Dubey, R. ,Bhushan, R. ,Fouad, M. A. ,Elkady, E. F. ,Csomor, V. ,Laufer, R. ,Pöstényi, Z. ,Kalász, H. ,Adeghate, E. ,Nurulain, S. M. ,Tekes, K. ,Adem, A. ,Kwiecień, A. ,Krzek, J. ,Gądek, M. ,Kuźma, Ł. ,Wysokińska, H. ,Dong, H. ,Wang, Y. ,Ou, Y. ,She, J. ,Shen, X. ,Li, J. ,Zhang, C. ,Liu, L. ,Xiong, W. ,Yan, R. Q. ,Liu, Y. N. ,Peng, S. W. ,Jiang, Z. Z. ,Chai, X. ,Qi, A. D. ,Wang, Y. F. , Establishment and validation of quantitative analysis of multi-components by single-marker for quality assessment of compound danshen preparations. Acta Chromatographica Vol. 26, no. 4/2014
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