Journal : Acta Chromatographica
Article : Gas chromatographic determination of parabens after in-situ derivatization and dispersive liquid-liquid microextraction

Authors :
Xu, L. N.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Gai, F. Y.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Mu, G. F.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Gao, Y.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Liu, C. J.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Luan, F.
Yantai University Department of Applied Chemistry Yantai 264005 P.R. China,
Mori, M.
Gunma University Department of Chemistry and Chemical Biology, Graduate School of Engineering 1-5-1 Tenjin-cho Kiryu 376-8515 Japan,
Ikeda, T.
Gunma University Department of Chemistry and Chemical Biology, Graduate School of Engineering 1-5-1 Tenjin-cho Kiryu 376-8515 Japan,
Itabashi, H.
Gunma University Department of Chemistry and Chemical Biology, Graduate School of Engineering 1-5-1 Tenjin-cho Kiryu 376-8515 Japan,
Soomro, R.
University of Sindh National Center of Excellence in Analytical Chemistry Jamshoro Pakistan,
Memon, S. Q.
University of Sindh Institute of Advance Research in Chemical Sciences Jamshoro Pakistan,
Ahmed, M. J.
University of Chittagong Laboratory of Analytical Chemistry, Department of Chemistry Chittagong 4331 Bangladesh,
Memon, N.
University of Sindh National Center of Excellence in Analytical Chemistry Jamshoro Pakistan, najmamemon@gmail.com,
Mallah, A.
University of Sindh M.A. Kazi Institute of Chemistry Jamshoro Pakistan,
Ravi, P. R.
BITS-Pilani Hyderabad Campus Pharmacy Department Ranga Reddy (Dist.) Jawaharnagar Andhra Pradesh India, rahulvats1983@gmail.com,
Aditya, N.
BITS-Pilani Hyderabad Campus Pharmacy Department Ranga Reddy (Dist.) Jawaharnagar Andhra Pradesh India, adityamurthy1212@gmail.com,
Vats, R.
BITS-Pilani Hyderabad Campus Pharmacy Department Ranga Reddy (Dist.) Jawaharnagar Andhra Pradesh India, rpunnarao@gmail.com,
Navaneethan, G.
Sona College of Technology (Anna University) Department of Sciences Salem 636 005 India,
Karunakaran, K.
Sona College of Technology (Anna University) Department of Sciences Salem 636 005 India, drkk@sonatech.ac.in,
Elango, K. P.
Gandhigram Rural Institute (Deemed University) Department of Chemistry Gandhigram 624 302 India,
Prichodko, A.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania,
Janenaite, E.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania,
Smitiene, V.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania,
Vickackaite, V.
Vilnius University Department of Analytical and Environmental Chemistry Naugarduko 24 LT-03225 Vilnius Lithuania, vida.vickackaite@chf.vu.lt,
Abstract : Dispersive liquid-liquid microextraction in combination with an in situ derivatization is suggested for parabens sampling and preconcentration. The derivatization was carried out with acetic anhydride under alkaline conditions maintained using di-potassium hydrogen phosphate. The effects of an extraction solvent type, extraction and disperser solvents volume, extraction time, and ionic strength of the solution on the extraction efficiency were investigated. Chlorobenzene containing n-hexadecane as internal standard was used as an extracting solvent and acetone was used as a disperser solvent. The calibration graphs were linear up to 10 mg mL-1, correlation coefficients were 0.997–0.999, enrichment factors were from 70 for methylparaben to 210 for butylparaben, and detection limits were 22, 4.2, 3.3, and 2.5 µg L−1 for methylparaben, ethylparaben, propylparaben, and butylparaben, respectively. Repeatabilities of the results were acceptable with relative standard deviations up to 11%. A possibility to apply the proposed method for parabens determination in water samples was demonstrated.

Keywords : dispersive liquid-liquid microextraction, gas chromatography, parabens, derivatization, water samples,
Publishing house : University of Silesia in Katowice
Publication date : 2012
Number : Vol. 24, no. 4
Page : 589 – 601

Bibliography
: 1 J.K. Lokhnauth and N.H. Snow, Anal. Chem., 77, 5938 (2005)
2 G. Shanmugam, B.R. Ramaswamy, V. Radhakrishnan, and H. Tao, Microchem. J., 96, 391 (2010)
3 P. Canosa, I. Rodriguez, E. Rubi, N. Negreira, and R. Cela, Anal. Chim. Acta, 575, 106 (2006)
4 T. Benijts, W. Lambert, and A. De Leenheer, Anal. Chem., 76, 704 (2004)
5 I. Gonzalez-Marino, J.B. Quintana, I. Rodriguez, S. Schrader, and M. Moeder, Anal. Chim. Acta, 684, 59 (2011)
6 A.M. Casas Ferreira, M. Moder, and M.E. Fernandez Laespada, Anal. Bioanal. Chem., 399, 945 (2011)
7 E. Villaverde-de-Saa, I. Gonzalez-Marino, J.B. Quintana, R. Rodil, I. Rodriguez, and R. Cela, Anal. Bioanal. Chem., 397, 2559 (2010)
8 J. Regueiro, M. Llompart, E. Psillakis, J.C. Garcia-Monteagudo, and C. Garcia-Jares, Talanta, 79, 1387 (2009)
9 J. Regueiro, E. Becerril, C. Garcia-Jares, and M. Llompart, J. Chromatogr. A, 1216, 4693 (2009)
10 T. Benijts, W. Lambert, and A. De Leenheer, Anal. Chem., 76, 704 (2004)
11 A. Prichodko, V. Sakociute, and V. Vickackaite, Chemija, 21, 112 (2010)
12 M. Saraji and S. Mirmahdieh, J. Sep. Sci., 32, 988 (2009)
13 S. Tayama, Y. Nakagawa, and K. Tayama, Mutat. Res., 649, 114 (2008)
14 P.D. Darbre, A. Aljarrah, W.R. Miller, N.G. Coldham, M.J. Sauer, and G.S. Pope, J. Appl. Toxicol., 24, 5 (2004)
15 P.D. Darbre and P.W. Harvey, J. Appl. Toxicol., 28, 561 (2008)
16 J.J. Strouse, T.R. Fears, M.A. Tucker, and A.S. Wayne, J. Clin. Oncol., 23, 4735 (2005)
17 M. Terasaki and M. Makino, Int. J. Environ. Anal. Chem., 88, 911 (2008)
18 A.M. Peek, Anal. Bioanal. Chem., 386, 907 (2006)
19 T. Okumura and Y. Nishikawa, Anal. Chim. Acta, 325, 175 (1996)
20 P. Canosa, I. Rodriguez, E. Rubi, M.H. Bollain, and R. Cela, J. Chromatogr. A, 1124, 3 (2006)
21 P. Canosa, I. Rodriguez, E. Rubi, and R. Cela, J. Chromatogr. A, 1072, 107 (2005)
22 V. Ciuvasovaite, E. Adomaviciute, and V. Vickackaite, Chemija, 18, 11 (2007)
23 Y.C. Fiamegos and C.D. Stalikas, Anal. Chim. Acta, 597, 32 (2007)
24 A. Prichodko, K. Jonusaite, and V. Vickackaite, Centr. Eur. J. Chem., 7, 285 (2009)
25 M.A. Farajzadeh, Gj. Djozan, and R. Fazeli Bakhtiyari, Talanta, 81, 1360 (2010)
26 M. Rezaee, Y. Assadi, M.R. Milani Hosseini, E. Aghaee, F. Ahmadi, and S. Berijani, J. Chromatogr. A, 1116, 1 (2006)
27 C. Basheer, H.K. Lee, and J.P. Obbard, J. Chromatogr. A, 968, 191 (2002)
28 Y. Lu, Q. Lin, G. Luo, and Y. Dai, Anal. Chim. Acta, 566, 259 (2006)
29 M.R.K. Zanjani, Y. Yamini, S. Shariati, and J.A. Jonsson, Anal. Chim. Acta, 585, 286 (2007)
30 H. Farahani, M.R. Ganjali, R. Dinarvand, and P. Norouzi, Talanta, 76, 718 (2008)
31 H.R. Sobhi, Y. Yamini, A. Esrafili, and R.H.H.B. Abadi, J. Chromatogr. A, 1196–1197, 28 (2008)
DOI :
Qute : Xu, L. N. ,Gai, F. Y. ,Mu, G. F. ,Gao, Y. ,Liu, C. J. ,Luan, F. ,Mori, M. ,Ikeda, T. ,Itabashi, H. ,Soomro, R. ,Memon, S. Q. ,Ahmed, M. J. ,Memon, N. ,Mallah, A. ,Ravi, P. R. ,Aditya, N. ,Vats, R. ,Navaneethan, G. ,Karunakaran, K. ,Elango, K. P. ,Prichodko, A. ,Janenaite, E. ,Smitiene, V. ,Vickackaite, V. ,Vickackaite, V. , Gas chromatographic determination of parabens after in-situ derivatization and dispersive liquid-liquid microextraction. Acta Chromatographica Vol. 24, no. 4/2012
facebook