Identification and simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice by LC-MS/MS

Czasopismo : Acta Chromatographica
Tytuł artykułu : Identification and simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice by LC-MS/MS

Autorzy :
Fatemi, M. H.
University of Mazandaran Faculty of Chemistry Babolsar Iran,
Hadjmohammadi, M. R.
University of Mazandaran Faculty of Chemistry Babolsar Iran, hdjmr@umz.ac.ir,
Shakeri, P.
University of Mazandaran Faculty of Chemistry Babolsar Iran,
Bhushan, R.
Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India, rbushfcy@iitr.ernet.in,
Lal, M.
Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India,
Thomas, S.
Jubilant Life Sciences Ltd. Analytical Research Department R&D Centre, C-26, Sector-59 Noida Uttar Pradesh 201 301 India, saji_thomas@jubl.com,
Paul, S. K.
Jubilant Life Sciences Ltd. Analytical Research Department R&D Centre, C-26, Sector-59 Noida Uttar Pradesh 201 301 India,
Agarwal, A.
Jubilant Life Sciences Ltd. Analytical Research Department R&D Centre, C-26, Sector-59 Noida Uttar Pradesh 201 301 India,
Mathela, C. S.
Kumaun University Department of Chemistry DSB Campus Nainital Uttarakhand 263 001 India,
Elgizawy, S. M.
Assuit University Analytical Chemistry Department, Faculty of Pharmacy 71515 Assuit Egypt,
Hassan, N. Y.
Cairo University Analytical Chemistry Department, Faculty of Pharmacy Kasr-El Aini Street 11562 Cairo Egypt,
Lotfy, H. M.
Cairo University Analytical Chemistry Department, Faculty of Pharmacy Kasr-El Aini Street 11562 Cairo Egypt,
Saleh, S. S.
October University for Modern Sciences and Arts (MSA) Analytical Chemistry Department, Faculty of Pharmacy 11787 6th October City Egypt, drsarahsalah@gmail.com,
Shakya, A.
Al-Ahliyya Amman University Faculty of Pharmacy and Medical Sciences PO Box 263 Amman 19328 Jordan, ashokshakya@hotmail.com,
Arafat, T.
Petra University Faculty of Pharmacy PO Box 961343 Amman Jordan,
Hakooz, N. M.
Zarqa University Faculty of Pharmacy Zarqa 13132 Jordan,
Abuawwad, A. N.
Jordan Center for Pharmaceutical Research PO Box 950435 Amman 11495 Jordan,
Al-Hroub, H.
Jordan Center for Pharmaceutical Research PO Box 950435 Amman 11495 Jordan,
Melhim, M.
Jordan Center for Pharmaceutical Research PO Box 950435 Amman 11495 Jordan,
Haliński, Ł.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland, lukaszh@chem.univ.gda.pl,
Śmigiel, D.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Czerwicka, M.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Paszkiewicz, M.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Kumirska, J.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Stepnowski, P.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Odeh, I.
Al-Quds University Chemistry and Chemical Technology Department P.O. Box 20002 Abu-Deis Palestine,
Abu-Lafi, S.
Al-Quds University Faculty of Pharmacy P.O. Box 20002 Abu-Deis Palestine, sabulafi@science.alquds.edu,
Al-Najjar, I.
Al-Quds University Chemistry and Chemical Technology Department P.O. Box 20002 Abu-Deis Palestine,
Znini, M.
University My Ismail Laboratoire des Substances Naturelles & Synthèse et Dynamique Moléculaire, Faculté des Sciences et Techniques Errachidia Morocco,
Majidi, L.
University My Ismail Laboratoire des Substances Naturelles & Synthèse et Dynamique Moléculaire, Faculté des Sciences et Techniques Errachidia Morocco, lmajidi@yahoo.fr,,
Desjobert, J. M.
Université de Corse UMR CNRS 6134, Laboratoire de Chimie des Produits Naturels, Faculté des Sciences et Techniques Corse France,
Paolini, J.
Université de Corse UMR CNRS 6134, Laboratoire de Chimie des Produits Naturels, Faculté des Sciences et Techniques Corse France,
Costa, J.
Université de Corse UMR CNRS 6134, Laboratoire de Chimie des Produits Naturels, Faculté des Sciences et Techniques Corse France,
Xie, J.
Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China,
Zhang, Y.
Tianjin University of Commerce Department of Pharmaceutical Engineering Tianjin 300134 China,
Wang, W.
Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China, wwq57@126.com,
Hou, J.
Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China,
Abstrakty : A new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice. An Eclipse Plus C18 column (I.D. 4.6 × 100 mm, 3.5 μm particle size; Agilent) was used in the analysis. Electrospray ionization (ESI)-tandem interface in the negative mode was performed, and multiple reaction monitoring (MRM) was employed with the precursor multiple reaction monitoring production combination for the determination of six analytes. The average recoveries ranged from 98.30% to 100.13% with relative standard deviations (RSDs) ≤ 1.95%, and limits of detection (LODs) ranged from 2.1 to 3.6 pg. The applicability of this analytical approach was confirmed by the successful analysis of six samples. The results indicated that the established method was validated, sensitive, and reliable for the determination of six analytes in licorice.

Słowa kluczowe : licorice, LC-MS/MS, simultaneous analysis, glycyrrhizin, liquiritin, licochalcone A,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2014
Numer : Vol. 26, no. 3
Strony : 507 – 516
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DOI :
Cytuj : Fatemi, M. H. ,Hadjmohammadi, M. R. ,Shakeri, P. ,Bhushan, R. ,Lal, M. ,Thomas, S. ,Paul, S. K. ,Agarwal, A. ,Mathela, C. S. ,Elgizawy, S. M. ,Hassan, N. Y. ,Lotfy, H. M. ,Saleh, S. S. ,Shakya, A. ,Arafat, T. ,Hakooz, N. M. ,Abuawwad, A. N. ,Al-Hroub, H. ,Melhim, M. ,Haliński, Ł. ,Śmigiel, D. ,Czerwicka, M. ,Paszkiewicz, M. ,Kumirska, J. ,Stepnowski, P. ,Odeh, I. ,Abu-Lafi, S. ,Al-Najjar, I. ,Znini, M. ,Majidi, L. ,Desjobert, J. M. ,Paolini, J. ,Costa, J. ,Xie, J. ,Zhang, Y. ,Wang, W. ,Hou, J. , Identification and simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice by LC-MS/MS. Acta Chromatographica Vol. 26, no. 3/2014
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