Journal : Acta Chromatographica
Article : Identification of chemical constituents in SiWu decoction by UHPLC-DAD-TOF/MS

Authors :
Fatemi, M. H.
University of Mazandaran Faculty of Chemistry Babolsar Iran,
Hadjmohammadi, M. R.
University of Mazandaran Faculty of Chemistry Babolsar Iran, hdjmr@umz.ac.ir,
Shakeri, P.
University of Mazandaran Faculty of Chemistry Babolsar Iran,
Bhushan, R.
Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India, rbushfcy@iitr.ernet.in,
Lal, M.
Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India,
Thomas, S.
Jubilant Life Sciences Ltd. Analytical Research Department R&D Centre, C-26, Sector-59 Noida Uttar Pradesh 201 301 India, saji_thomas@jubl.com,
Paul, S. K.
Jubilant Life Sciences Ltd. Analytical Research Department R&D Centre, C-26, Sector-59 Noida Uttar Pradesh 201 301 India,
Agarwal, A.
Jubilant Life Sciences Ltd. Analytical Research Department R&D Centre, C-26, Sector-59 Noida Uttar Pradesh 201 301 India,
Mathela, C. S.
Kumaun University Department of Chemistry DSB Campus Nainital Uttarakhand 263 001 India,
Elgizawy, S. M.
Assuit University Analytical Chemistry Department, Faculty of Pharmacy 71515 Assuit Egypt,
Hassan, N. Y.
Cairo University Analytical Chemistry Department, Faculty of Pharmacy Kasr-El Aini Street 11562 Cairo Egypt,
Lotfy, H. M.
Cairo University Analytical Chemistry Department, Faculty of Pharmacy Kasr-El Aini Street 11562 Cairo Egypt,
Saleh, S. S.
October University for Modern Sciences and Arts (MSA) Analytical Chemistry Department, Faculty of Pharmacy 11787 6th October City Egypt, drsarahsalah@gmail.com,
Shakya, A.
Al-Ahliyya Amman University Faculty of Pharmacy and Medical Sciences PO Box 263 Amman 19328 Jordan, ashokshakya@hotmail.com,
Arafat, T.
Petra University Faculty of Pharmacy PO Box 961343 Amman Jordan,
Hakooz, N. M.
Zarqa University Faculty of Pharmacy Zarqa 13132 Jordan,
Abuawwad, A. N.
Jordan Center for Pharmaceutical Research PO Box 950435 Amman 11495 Jordan,
Al-Hroub, H.
Jordan Center for Pharmaceutical Research PO Box 950435 Amman 11495 Jordan,
Melhim, M.
Jordan Center for Pharmaceutical Research PO Box 950435 Amman 11495 Jordan,
Haliński, Ł.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland, lukaszh@chem.univ.gda.pl,
Śmigiel, D.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Czerwicka, M.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Paszkiewicz, M.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Kumirska, J.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Stepnowski, P.
University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland,
Odeh, I.
Al-Quds University Chemistry and Chemical Technology Department P.O. Box 20002 Abu-Deis Palestine,
Abu-Lafi, S.
Al-Quds University Faculty of Pharmacy P.O. Box 20002 Abu-Deis Palestine, sabulafi@science.alquds.edu,
Al-Najjar, I.
Al-Quds University Chemistry and Chemical Technology Department P.O. Box 20002 Abu-Deis Palestine,
Znini, M.
University My Ismail Laboratoire des Substances Naturelles & Synthèse et Dynamique Moléculaire, Faculté des Sciences et Techniques Errachidia Morocco,
Majidi, L.
University My Ismail Laboratoire des Substances Naturelles & Synthèse et Dynamique Moléculaire, Faculté des Sciences et Techniques Errachidia Morocco, lmajidi@yahoo.fr,,
Desjobert, J. M.
Université de Corse UMR CNRS 6134, Laboratoire de Chimie des Produits Naturels, Faculté des Sciences et Techniques Corse France,
Paolini, J.
Université de Corse UMR CNRS 6134, Laboratoire de Chimie des Produits Naturels, Faculté des Sciences et Techniques Corse France,
Costa, J.
Université de Corse UMR CNRS 6134, Laboratoire de Chimie des Produits Naturels, Faculté des Sciences et Techniques Corse France,
Xie, J.
Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China,
Zhang, Y.
Tianjin University of Commerce Department of Pharmaceutical Engineering Tianjin 300134 China,
Wang, W.
Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China, wwq57@126.com,
Hou, J.
Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China,
Zhu, M.
The First Affiliated Hospital of Nanjing University of Chinese Medicine West Phoenix Street, 150-1 210036 Nanjing China,
Duan, J.
Nanjing University of Chinese Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae Xianlin Road 138 210023 Nanjing China,
Tang, Y. P.
Nanjing University of Chinese Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae Xianlin Road 138 210023 Nanjing China,
Guo, J. M.
Nanjing University of Chinese Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae Xianlin Road 138 210023 Nanjing China,
Shang, E. X.
Nanjing University of Chinese Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae Xianlin Road 138 210023 Nanjing China,
Zhu, Z. H.
Nanjing University of Chinese Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae Xianlin Road 138 210023 Nanjing China, zhumin0902@163.com,
Abstract : An efficient and robust method for analyzing constituents of a well-known traditional Chinese medicine (TCM) formula SiWu decoction (SWD) contains AngelicaeSinensis Radix (ASR), Chuanxiong Rhizoma (CR), Paeoniae Radix Alba (PRA), and RehmanniaeRadix Praeparata (RRP) by ultra high-performance liquid chromatography (UHPLC)/time-of-flight mass spectrometry (TOF-MS) was established. The method efficiently applied to the separation of 75 compounds, including organic acids, phthalides, phenylpropanoid glycosides, iridoid glycosides, monoterpene glycosides, and galloyl glycosides in the complex prescription, 52 compounds in this study can be unambiguously identified or tentatively characterized. The separation was achieved within 20 min at the optimized chromatographic conditions. Our study provided a reliable and high-efficient method for the understanding of the chemical basis of SWD.

Keywords : SiWu decoction, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Alba, Rehmanniae Radix Praeparata,
Publishing house : University of Silesia in Katowice
Publication date : 2014
Number : Vol. 26, no. 3
Page : 517 – 537

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DOI :
Qute : Fatemi, M. H. ,Hadjmohammadi, M. R. ,Shakeri, P. ,Bhushan, R. ,Lal, M. ,Thomas, S. ,Paul, S. K. ,Agarwal, A. ,Mathela, C. S. ,Elgizawy, S. M. ,Hassan, N. Y. ,Lotfy, H. M. ,Saleh, S. S. ,Shakya, A. ,Arafat, T. ,Hakooz, N. M. ,Abuawwad, A. N. ,Al-Hroub, H. ,Melhim, M. ,Haliński, Ł. ,Śmigiel, D. ,Czerwicka, M. ,Paszkiewicz, M. ,Kumirska, J. ,Stepnowski, P. ,Odeh, I. ,Abu-Lafi, S. ,Al-Najjar, I. ,Znini, M. ,Majidi, L. ,Desjobert, J. M. ,Paolini, J. ,Costa, J. ,Xie, J. ,Zhang, Y. ,Wang, W. ,Hou, J. ,Zhu, M. ,Duan, J. ,Tang, Y. P. ,Guo, J. M. ,Shang, E. X. ,Zhu, Z. H. ,Zhu, Z. H. , Identification of chemical constituents in SiWu decoction by UHPLC-DAD-TOF/MS. Acta Chromatographica Vol. 26, no. 3/2014
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