Multi-composition analysis in Radix Aconiti Lateralis by single marker quantitation

Czasopismo : Acta Chromatographica
Tytuł artykułu : Multi-composition analysis in Radix Aconiti Lateralis by single marker quantitation

Autorzy :
Kuc, J.
Cracow University of Technology Department of Chemical Engineering and Technology, Department of Analytical Chemistry Warszawska 24 31-155 Cracow Poland, jkuc@chemia.pk.edu.pl,
Grochowalski, A.
Cracow University of Technology Department of Chemical Engineering and Technology, Department of Analytical Chemistry Warszawska 24 31-155 Cracow Poland,
Mach, S.
Institute of Public Health Ostrava Centre of Hygienic Laboratories Dobrá 240 739 51 Frýdek-Místek Czech Republic,
Placha, D.
VŠB-Technical University of Ostrava Centrum Nanotechnology 17 Listopadu 15/2172 708 33 Ostrava Czech Republic,
Furusawa, N.
Osaka City University Graduate School of Human Life Science Osaka 558-8585 Japan,
Stoilova, N.
Bulgarian Food Safety Agency Central Laboratory of Veterinary Control and Ecology (CLVCE) 5 “Iskarsko shousse” str., 1528 Sofia Bulgaria, nadqstoilova@abv.bg,
Surleva, A.
University of Chemical Technology and Metallurgy Analytical Chemistry Department 8 “St. Kl. Ohridski” blvd., 1756 Sofia Bulgaria,
Stoev, G.
Bulgarian Food Safety Agency Central Laboratory of Veterinary Control and Ecology (CLVCE) 5 “Iskarsko shousse” str., 1528 Sofia Bulgaria,
Popovic, N.
Lafayette College Department of Chemistry Easton PA USA,
Sherma, J.
Lafayette College Department of Chemistry Easton PA USA, shermaj@lafayette.edu,
Dixit, S.
Yeungnam University Department of Chemistry Gyeongsan 712-749 South Korea, drdixit.shuchi@gmail.com,
Dubey, R.
riturajdubey0@gmail.com,
Bhushan, R.
Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India, rbushfcy@iitr.ernet.in,
Fouad, M. A.
Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini St. Cairo 11562 Egypt, merro911@yahoo.com,
Elkady, E. F.
Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini St. Cairo 11562 Egypt,
Csomor, V.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Laufer, R.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Pöstényi, Z.
Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary,
Kalász, H.
Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary, huba.kalasz@gmail.com,
Adeghate, E.
United Arab Emirates University Department of Anatomy Al Ain UAE,
Nurulain, S. M.
United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain UAE,
Tekes, K.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Adem, A.
United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain UAE,
Kwiecień, A.
Jagiellonian University Medical College, Faculty of Pharmacy Department of Inorganic and Analytical Chemistry 9 Medyczna Street 30-688 Kraków Poland,
Krzek, J.
Jagiellonian University Medical College, Faculty of Pharmacy Department of Inorganic and Analytical Chemistry 9 Medyczna Street 30-688 Kraków Poland, jankrzek@cm-uj.krakow.pl,
Gądek, M.
Jagiellonian University Medical College, Faculty of Pharmacy Department of Inorganic and Analytical Chemistry 9 Medyczna Street 30-688 Kraków Poland,
Kuźma, Ł.
Medical University of Łódź Department of Biology and Pharmaceutical Botany Muszyńskiego 1 st. 90-151 Łódź Poland, lukasz.kuzma@umed.lodz.p,
Wysokińska, H.
Medical University of Łódź Department of Biology and Pharmaceutical Botany Muszyńskiego 1 st. 90-151 Łódź Poland,
Dong, H.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China, hongxingd6@yahoo.com.cn,
Wang, Y.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Ou, Y.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
She, J.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Shen, X.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Li, J.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Zhang, C.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Liu, L.
Harbin Engineering University Polymer Materials Research Center, Key Laboratory of Superlight Materials and Surface Technology Ministry of Education. College of Material Science and Chemical Engineering Harbin 150001 China,
Xiong, W.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Yan, R. Q.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Liu, Y. N.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Peng, S. W.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Jiang, Z. Z.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Chai, X.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Qi, A. D.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China,
Wang, Y. F.
Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China, wangyuefei_2006@hotmail.com,
Li, J. R.
Chinese Academy of Sciences Chengdu Institute of Biology Chengdu 610041 PR China,
Li, D. X.
Sichuan Academy of Chinese Medicine Sciences Sichuan Key Laboratory of Quality and Innovation Research of Chinese Materia Medica Chengdu 610041 PR China,
Li, L.
Waters China Limited Block 41, 1387 Zhangdong Road, Pudong New District Shanghai 201203 PR China,
Deng, W. L.
Sichuan Academy of Chinese Medicine Sciences Sichuan Key Laboratory of Quality and Innovation Research of Chinese Materia Medica Chengdu 610041 PR China,
Ding, L. S.
Chinese Academy of Sciences Chengdu Institute of Biology Chengdu 610041 PR China,
Xu, H. X.
Shanghai University of Traditional Chinese Medicines Shanghai 201203 PR China,
Zhou, Y.
Chinese Academy of Sciences Chengdu Institute of Biology Chengdu 610041 PR China, zhouyan@cib.ac.cn,
Yang, H.
Zhejiang Chinese Medical University College of Pharmaceutical Sciences Hangzhou, Zhejiang China,
Yin, H.
Zhejiang Chinese Medical University College of Pharmaceutical Sciences Hangzhou, Zhejiang China, maryyinhua@163.com,
Wang, Z.
Zhejiang Chinese Medical University Traumatology Institute Hangzhou, Zhejiang China,
Fan, L.
Zhejiang Chinese Medical University College of Pharmaceutical Sciences Hangzhou, Zhejiang China,
Li, Q.
Zhejiang Chinese Medical University College of Pharmaceutical Sciences Hangzhou, Zhejiang China,
Zhu, X.
Zhejiang Chinese Medical University College of Pharmaceutical Sciences Hangzhou, Zhejiang China,
Abstrakty : Traditional Chinese medicine (TCM) has been widely used in many countries for thousands of years and played an indispensable role in the prevention and treatment of diseases, especially the complicated and chronic ones. However, the application of TCM in diseases is still not fully recognized by people around the world, the main reason is that Chinese herb is a very complex mixture containing hundreds of different components. Thus, it is essential to make quality control and evaluation of TCM. A new quality evaluation method, quantitative analysis of multi-components by single marker (QAMS), was developed to the quality control of alkaloids in TCM, a case study on Radix aconiti lateralis, named Fuzi in Chinese. Six alkaloids, including aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylmesaconine, and benzoylhypaconine, were selected as main components to evaluate the quality of Radix aconiti lateralis. The feasibility and accuracy of QAMS were checked by the external standard method, and various high-performance liquid chromatographic instruments and chromatographic conditions were investigated to verify its applicability. Using aconitine as the internal reference substance and the content of aconitine was calculated according to relative correction factors by high-performance liquid chromatography. The present results showed that there was no significant difference observed between the QAMS method and the external standard method with the relative average deviations less than 3.0%, and QAMS is an effective way to control the quality of herbal medicines and seems to be a convenient and accurate approach to analyze multi-composition when reference substances are unavailable.

Słowa kluczowe : quantitative analysis of multi-components by single marker, relative correction factor, Radix aconiti,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2014
Numer : Vol. 26, no. 4
Strony : 727 – 737
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DOI :
Cytuj : Kuc, J. ,Grochowalski, A. ,Mach, S. ,Placha, D. ,Furusawa, N. ,Stoilova, N. ,Surleva, A. ,Stoev, G. ,Popovic, N. ,Sherma, J. ,Dixit, S. ,Dubey, R. ,Bhushan, R. ,Fouad, M. A. ,Elkady, E. F. ,Csomor, V. ,Laufer, R. ,Pöstényi, Z. ,Kalász, H. ,Adeghate, E. ,Nurulain, S. M. ,Tekes, K. ,Adem, A. ,Kwiecień, A. ,Krzek, J. ,Gądek, M. ,Kuźma, Ł. ,Wysokińska, H. ,Dong, H. ,Wang, Y. ,Ou, Y. ,She, J. ,Shen, X. ,Li, J. ,Zhang, C. ,Liu, L. ,Xiong, W. ,Yan, R. Q. ,Liu, Y. N. ,Peng, S. W. ,Jiang, Z. Z. ,Chai, X. ,Qi, A. D. ,Wang, Y. F. ,Li, J. R. ,Li, D. X. ,Li, L. ,Deng, W. L. ,Ding, L. S. ,Xu, H. X. ,Zhou, Y. ,Yang, H. ,Yin, H. ,Wang, Z. ,Fan, L. ,Li, Q. ,Zhu, X. , Multi-composition analysis in Radix Aconiti Lateralis by single marker quantitation. Acta Chromatographica Vol. 26, no. 4/2014
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