On simple experimental evidence confirmed by HPLC data of supramolecular aggregation and aggregate mobility with S(+)-naproxen in aqueous ethanol solution

Czasopismo : Acta Chromatographica
Tytuł artykułu : On simple experimental evidence confirmed by HPLC data of supramolecular aggregation and aggregate mobility with S(+)-naproxen in aqueous ethanol solution

Autorzy :
Sajewicz, M.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Gontarska, M.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Kronenbach, D.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Berry, E.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Kowalska, T.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland, teresa.kowalska@us.edu.pl,
Deshpande, P. B.
A.I.S.S.M.S. College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road Pune 411001 MH India, padmanabh77@yahoo.co.in,
Gandhi, S. V.
A.I.S.S.M.S. College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road Pune 411001 MH India,
Gaikwad, N. V.
A.I.S.S.M.S. College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road Pune 411001 MH India,
Khandagle, K. S.
A.I.S.S.M.S. College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road Pune 411001 MH India,
Sateesh, J. N.
PRRM College of Pharmacy Department of Chemistry Kadapa Andhra Pradesh India, nagasateesh@gmail.com,
Subba Reedy, G. V.
JNTUA College of Engineering Department of Chemistry Pulivendula, Y.S.R (Kadapa) Andhra Pradesh India,
Jayaveera, K. N.
awaharlal Nehru Technological University Anantapur Oil Technology Research Institute Anantapur Andhra Pradesh India,
Dhayalamurthi, S.
Mother Theresa Post Graduate & Research Institute of Health Sciences Department of Chemistry, College of Pharmacy Gorimedu Puducherry India,
Anandakumar, K.
Adhiparasakthi College of Pharmacy Department of Pharmaceutical Analysis Melmaruvathur 603 319 Tamil Nadu India, anandkarunakaran@gmail.com,
Jothieswari, D.
Adhiparasakthi College of Pharmacy Department of Pharmaceutical Analysis Melmaruvathur 603 319 Tamil Nadu India,
Subathrai, R.
Adhiparasakthi College of Pharmacy Department of Pharmaceutical Analysis Melmaruvathur 603 319 Tamil Nadu India,
Santhi, D. V.
Adhiparasakthi College of Pharmacy Department of Pharmaceutical Analysis Melmaruvathur 603 319 Tamil Nadu India,
Vetrichelvan, T.
Adhiparasakthi College of Pharmacy Department of Pharmaceutical Analysis Melmaruvathur 603 319 Tamil Nadu India,
Shah, D. A.
Indukaka Ipcowala College of Pharmacy P.B. No. 53 New Vallabh Vidyanagar 388 121 Dist. Anand Gujarat India, dimalgroup@yahoo.com,
Bhatt, K. K.
Indukaka Ipcowala College of Pharmacy P.B. No. 53 New Vallabh Vidyanagar 388 121 Dist. Anand Gujarat India,
Baldania, S. L.
Indukaka Ipcowala College of Pharmacy P.B. No. 53 New Vallabh Vidyanagar 388 121 Dist. Anand Gujarat India,
Tian, M.
Inha University Department of Chemical Engineering 253 Yonghyun-Dong, Nam-Ku Incheon 402-751 Korea,
Li, S.
Inha University Department of Chemical Engineering 253 Yonghyun-Dong, Nam-Ku Incheon 402-751 Korea,
Row, K. H.
Inha University Department of Chemical Engineering 253 Yonghyun-Dong, Nam-Ku Incheon 402-751 Korea, rowkho@inha.ac.kr,
Azar, P. A.
Islamic Azad University, Science and Research Branch Department of Chemistry P.O. Box 14155/4933 Tehran Iran, pabroomand@yahoo.com,
Porgham-Daryasari, A.
Islamic Azad University, Science and Research Branch Department of Chemistry P.O. Box 14155/4933 Tehran Iran,
Saber-Tehrani, M.
Islamic Azad University, Science and Research Branch Department of Chemistry P.O. Box 14155/4933 Tehran Iran,
Soleimani, M.
Islamic Azad University, Lahijan Branch Department of Chemistry, Faculty of Science P.O. Box 1616 Lahijan Iran,
Patel, M. B.
Atmiya Institute of Pharmacy Department of Pharmacognosy and Phytochemistry Yogidham Gurukul, Kalawad Road Rajkot Gujarat India, mayur.pharma@gmail.com,
Mishra, S. H.
The M.S. University of Baroda Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan Vadodara 390 001 Gujarat India,
Hashemi, P.
Lorestan University Department of Chemistry, Faculty of Science Khoramabad Iran, payman_hashemi@yahoo.com,
Yarahmadi, A.
Lorestan University Department of Chemistry, Faculty of Science Khoramabad Iran,
Shamizadeh, M.
Lorestan University Department of Chemistry, Faculty of Science Khoramabad Iran,
Khademi, K.
Agriculture and Natural Resource Research Center P.O. Box 348 Khoramabad Iran,
Amir, M.
amia Hamdard Tissue Culture Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy New Delhi – 62 India,
Ahmad, A.
amia Hamdard Tissue Culture Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy New Delhi – 62 India,
Siddique, N. A.
amia Hamdard Tissue Culture Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy New Delhi – 62 India,
Mujeeb, M.
amia Hamdard Tissue Culture Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy New Delhi – 62 India, mujeeb_zaidi@yahoo.com,
Ahmad, S.
amia Hamdard Tissue Culture Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy New Delhi – 62 India,
Siddique, W. A.
Jamia Hamdard Department of Biochemistry, Faculty of Science New Delhi – 62 India,
Hridya, V. K.
Manonmaniam Sundaranar University Centre for GeoTechnology Abishekapatti, Tirunelveli Tamilnadu 627 012 India, hridyavk@yahoo.com,
Godson, P. S.
Manonmaniam Sundaranar University Centre for GeoTechnology Abishekapatti, Tirunelveli Tamilnadu 627 012 India,
Chandrasekar, N.
Manonmaniam Sundaranar University Centre for GeoTechnology Abishekapatti, Tirunelveli Tamilnadu 627 012 India,
Sajewicz, M.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Gontarska, M.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Kowalska, T.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland, teresa.kowalska@us.edu.pl,
Abstrakty : In our earlier studies performed with the use of thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), polarimetry, and several other instrumental techniques, we have provided abundant experimental evidence for the oscillatory chiral conversion and the oscillatory condensation of the low-molecular-weight carboxylic acids from the groups of profen drugs, amino acids, and hydroxy acids. We have also proposed several kinetic-diffusive models aimed at elucidation of these striking phenomena, which in the diffusive term assumed contribution from the density inhomogeneity of the investigated liquid systems. Moreover, each model laid special emphasis on the importance of cyclic H-bonded carboxylic acid homodimers of the SS and RR type. In this paper, we introduce a simple experimental approach enabling convenient registration of the density inhomogeneity in the S(+)-naproxen solution prepared in 70% aqueous ethanol. To this effect, we use a zooming scanner that is able to scan this solution in a Petri dish placed in UV light (λ = 254 nm). Scanning in the selected time intervals allows tracing the dynamics of supramolecular aggregation of the investigated profen drugs. The mobility of these aggregates can probably result from the energy released in the process of chemical polycondensation. The obtained results seem to correlate well with those originating from HPLC, and the relevant conclusions are drawn. It seems possible that the zooming scanner can prove helpful in monitoring some other interesting chemical processes as well, thus contributing to the studies on the mechanism and kinetics of the nonlinear organic reactions.

Słowa kluczowe : S(+)-naproxen, oscillatory chiral conversion, oscillatory polycondensation, H-bonding, supramolecular self-organization, HPLC, zooming scanning,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2012
Numer : Vol. 24, no. 1
Strony : 131 – 141
Bibliografia : 1 M. Sajewicz, R. Piętka, A. Pieniak, and T. Kowalska, Acta Chromatogr., 15, 131–149 (2005)
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DOI :
Cytuj : Sajewicz, M. ,Gontarska, M. ,Kronenbach, D. ,Berry, E. ,Kowalska, T. ,Deshpande, P. B. ,Gandhi, S. V. ,Gaikwad, N. V. ,Khandagle, K. S. ,Sateesh, J. N. ,Subba Reedy, G. V. ,Jayaveera, K. N. ,Dhayalamurthi, S. ,Anandakumar, K. ,Jothieswari, D. ,Subathrai, R. ,Santhi, D. V. ,Vetrichelvan, T. ,Shah, D. A. ,Bhatt, K. K. ,Baldania, S. L. ,Tian, M. ,Li, S. ,Row, K. H. ,Azar, P. A. ,Porgham-Daryasari, A. ,Saber-Tehrani, M. ,Soleimani, M. ,Patel, M. B. ,Mishra, S. H. ,Hashemi, P. ,Yarahmadi, A. ,Shamizadeh, M. ,Khademi, K. ,Amir, M. ,Ahmad, A. ,Siddique, N. A. ,Mujeeb, M. ,Ahmad, S. ,Siddique, W. A. ,Hridya, V. K. ,Godson, P. S. ,Chandrasekar, N. ,Sajewicz, M. ,Gontarska, M. ,Kowalska, T. , On simple experimental evidence confirmed by HPLC data of supramolecular aggregation and aggregate mobility with S(+)-naproxen in aqueous ethanol solution. Acta Chromatographica Vol. 24, no. 1/2012
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