Journal : Acta Chromatographica
Article : On the spontaneous abiotic peptization of phenylglycine in an aqueous medium

Authors :
Turło, J.
Medical University of Warsaw Department of Drug Technology 1 Banacha Street 02-097 Warsaw Poland Medical University of Warsaw Faculty of Pharmacy 1 Banacha Street 02-097 Warsaw Poland, jadwiga.turlo@wum.edu.p,
Komsta, Ł.
Medical University of Lublin Chair and Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland Medical University of Lublin Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy Chodźki 1 20-093 Lublin Pola, lukasz.komsta@am.lublin.pl,
Vasta, J. D.
Lafayette College Department of Chemistry Easton PA 18042-1782 USA Lafayette College Department of Biology Easton PA 18042-1782 USA, shermaj@mail.lafayette.edu,
Sajewicz, M.
Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland, kowalska@us.edu.pl,
Raju, Ch. B. V. N.
Aurobindo Pharma Limited Srikakulam Dist. Pydibhimavaram 532 409 India Andhra University Department of Inorganic and Analytical Chemistry Visakhapatnam 530 003 India, chbvn_5@yahoo.co.in,
Shende, P.
NMIMS University School of Pharmacy and Technology Management V.L. Mehta Road, Vile Parle (W) Mumbai 400056 India, shendepravin94@yahoo.co.in,
Dhaneshwar, S. R.
Bharati Vidyapeeth University, Poona College of Pharmacy Department of Pharmaceutical Chemistry Pune 411038 India, sunil.dhaneshwar@gmail.com,
Thakur, A. K.
University Institute of Chemical Technology 1A-286, Medicinal Natural Products Research Laboratory, Pharmaceutical Division Nathalal Parikh Marg, Matunga Mumbai 400 019 Maharastra India Pharmanza Herbal Pvt. Ltd Plot no 214, Near Vadadia Patiya, Borsad-T, achalthakur@gmail.com,
Niranjan, A.
National Botanical Research Institute (Council of Scientific and Industrial Research) Central Instrumentation Facility Lucknow 226 001 India, lehrinbri@yahoo.com,
Kumar, T.
Indian Statistical Institute Agricultural and Ecological Research Unit 203 B.T. Road Kolkata 700 108 India University of Calcutta Department of Chemistry, College of Science 92 APC Road Kolkata 700 009 India, tanumikumar@yahoo.co.in,
Haliński, Ł. P.
University of Gdańsk Department of Environmental Analysis, Faculty of Chemistry Sobieskiego 18 80-952 Gdańsk Poland, lukaszh@chem.univ.gda.pl,
Hashemi, P.
Lorestan University Department of Chemistry, Faculty of Science Khoramabad Iran Agriculture and Natural Resource Research Center P.O. Box 348 Khoramabad Iran, payman_hashemi@yahoo.com,
Sajewicz, M.
Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland, kowalska@us.edu.pl,
Abstract : In this report we provide thin-layer chromatographic evidence that phenylglycine dissolved in 70% aqueous ethanol and kept at ambient temperature (22°C) undergoes spontaneous peptization, as additionally confirmed by use of the biuret test. It was also shown that an important precondition for instantaneous peptization of phenylglycine is the simultaneous presence of the R and S antimers in solution, and the most spectacular peptization effect is obtained with racemic R,S -phenylglycine. An assumption is made that polycondensation of phenylglycine results from its ability to undergo spontaneous oscillatory chiral conversion and can be regarded as a step following enolization, and competitive with chiral conversion.

Keywords : phenylglycine, abiotic peptization, oscillatory chiral conversion,
Publishing house : University of Silesia in Katowice
Publication date : 2009
Number : Vol. 21, no. 1
Page : 151 – 160

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DOI :
Qute : Turło, J. ,Komsta, Ł. ,Vasta, J. D. ,Sajewicz, M. ,Raju, Ch. B. V. N. ,Shende, P. ,Dhaneshwar, S. R. ,Thakur, A. K. ,Niranjan, A. ,Kumar, T. ,Haliński, Ł. P. ,Hashemi, P. ,Sajewicz, M. ,Sajewicz, M. , On the spontaneous abiotic peptization of phenylglycine in an aqueous medium. Acta Chromatographica Vol. 21, no. 1/2009
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