Specific mobility of selected phytochemicals in thin-layer chromatographic systems and its possible relevance to pharmacokinetics

Czasopismo : Acta Chromatographica
Tytuł artykułu : Specific mobility of selected phytochemicals in thin-layer chromatographic systems and its possible relevance to pharmacokinetics

Autorzy :
Patil, A. N.
Pravara Rural College of Pharmacy Department of Pharmacognosy Pravaranagar, Loni 413736 Maharashtra India,
Nirmal, S. A.
Pravara Rural College of Pharmacy Department of Pharmacognosy Pravaranagar, Loni 413736 Maharashtra India, nirmalsunil@rediffmail.com,
Chavan, A. K.
Pravara Rural College of Pharmacy Department of Pharmacognosy Pravaranagar, Loni 413736 Maharashtra India,
Zhou, L.
China Agricultural University Department of Applied Chemistry, College of Science Beijing 100193 China,
Xu, J.
China Agricultural University Department of Applied Chemistry, College of Science Beijing 100193 China,
Luan, L.
China Agricultural University Department of Applied Chemistry, College of Science Beijing 100193 China,
Ma, J.
China Agricultural University Department of Applied Chemistry, College of Science Beijing 100193 China,
Gong, Y.
Ministry of Agriculture Institute for the Control of Agrochemicals Beijing 100026 China,
Qin, D.
Ministry of Agriculture Institute for the Control of Agrochemicals Beijing 100026 China,
Pan, C.
China Agricultural University Department of Applied Chemistry, College of Science Beijing 100193 China,
Jinlong, M.
Zhejiang University Department of Chemical and Biological Engineering Hangzhou 310027 China,
Guobin, J.
Dalian Nationalities University Environment and Resources College Dalian 11660 China,
Bo, J.
Dalian Nationalities University Life Science College Dalian 116600 China,
Hua, J.
Zhejiang University Department of Chemical and Biological Engineering Hangzhou 310027 China,
Montejo, C.
Universidad CEU San Pablo Departamento de Ciencias Farmacéuticas y de la Alimentación, Área de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia 28668 Madrid Spain, montejo@ceu.es,
Civera, C.
Universidad Complutense de Madrid Departamento de Química Física II, Facultad de Farmacia 28040 Madrid Spain,
Barcia, E.
Universidad Complutense de Madrid Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia 28040 Madrid Spain,
Negro, S.
Universidad Complutense de Madrid Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia 28040 Madrid Spain,
Fernández-Carballido, A.
Universidad Complutense de Madrid Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia 28040 Madrid Spain,
Czauderna, M.
Polish Academy of Sciences The Kielanowski Institute of Animal Physiology and Nutrition 05-110 Jabłonna Poland, mr.czauderna@gmail.com,
Marounek, M.
Prague-Uhříněves The Institute of Animal Science Prague Czech Republic,
Duskova, D.
Prague-Uhříněves The Institute of Animal Science Prague Czech Republic,
Kowalczyk, J.
Polish Academy of Sciences The Kielanowski Institute of Animal Physiology and Nutrition 05-110 Jabłonna Poland,
Konda, R. K.
Hindu College of Pharmacy Department of Pharmaceutical Chemistry Amaravathi Road Guntur Andhrapradesh 522002 India, victory2ravi@yahoo.co.in,
Chandu, B. R.
Donbosco College of Pharmacy Department of Pharmaceutical Sciences Pulladigunta Guntur 522201 India,
Challa, B. R.
Nirmala College of Pharmacy Department of Pharmaceutical Analysis Madras Road Kadapa Andhrapradesh 516002 India, baluchalla_99@yahoo.com,
Chandrasekhar, K. B.
Jawaharlal Nehru Technological University Department of Chemistry Anantapur 515002 India,
Shen, Y.
Jiangsu University School of Pharmacy Zhenjiang China,
Yang, H.
Jiangsu University School of Pharmacy Zhenjiang China,
Xia, G.
Jiangsu University School of Pharmacy Zhenjiang China,
Wang, J.
Jiangsu University School of Pharmacy Zhenjiang China,
Cai, B.
Nanjing University of Chinese Medicine Jiangsu Key Laboratory of Chinese Medicine Processing, SATCM Key Laboratory of Standardization for Chinese Medicine Processing Nanjing China,
Jia, X.
Jiangsu University School of Pharmacy Zhenjiang China, jxiaobin2005@hotmail.com,
Nurulain, S. M.
United Arab Emirates University Department of Pharmacology and Pharmacotherapy Al Ain United Arab Emirates,
Kalász, H.
Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary, huba.kalasz@gmail.com,
Szegi, P.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Kuca, K.
University Hospital Biomedical Research Center Hradec Kralove Czech Republic,
Adem, A.
United Arab Emirates University Department of Pharmacology and Pharmacotherapy Al Ain United Arab Emirates,
Hasan, M. Y. B.
United Arab Emirates University Department of Pharmacology and Pharmacotherapy Al Ain United Arab Emirates,
Hashemi, F.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Tekes, K.
Semmelweis University Department of Pharmacodynamics Budapest Hungary,
Sangoi, M. S.
Federal University of Rio Grande do Sul Faculty of Pharmacy 90610-000 Porto Alegre-RS Brazil, maxsilvasangoi@yahoo.com.br,
Wrasse-Sangoi, M.
Federal University of Santa Maria Department of Industrial Pharmacy 97105-900 Santa Maria-RS Brazil,
Hurtado, F. K.
Federal University of Rio Grande do Sul Faculty of Pharmacy 90610-000 Porto Alegre-RS Brazil,
Rolim, C. M. B.
Federal University of Santa Maria Department of Industrial Pharmacy 97105-900 Santa Maria-RS Brazil,
Walorczyk, S.
Institute of Plant Protection — National Research Institute Department of Pesticide Residue Research Władysława Węgorka 20 60-318 Poznań Poland, s_walorczyk@tlen.pl,
Li, W.
Jilin Agricultural University College of Chinese Medicinal Material Changchun 130118 China,
Shi, L. L.
Jilin Agricultural University College of Chinese Medicinal Material Changchun 130118 China,
Han, L. Q.
Jilin Agricultural University College of Chinese Medicinal Material Changchun 130118 China,
Zhang, J.
Jilin Agricultural University College of Chinese Medicinal Material Changchun 130118 China, zhjing0701@163.com,
Mirjalili, M. H.
Shahid Beheshti University Medicinal Plants and Drugs Research Institute G.C., Evin Tehran Iran,
Navarro, A.
National Autonomous University of Mexico Department of Food and Biotechnology, Faculty of Chemistry Ciudad de México 04510 Mexico,
Hernández, L.
Universidad Autónoma Metropolitana-Xochimilco Departamento de Sistemas Biológicos Calz. del Hueso 1100, Col. Villa Quietud 04960 México, D. F. México,
Jáuregui, O.
Universitat de Barcelona Scientific & Technological Centers (CCiTUB) c/Baldiri i Reixach 10-12 08028 Barcelona Spain,
Bonfill, M.
Universitat de Barcelona Laboratori de Fisiologia Vegetal, Facultat de Farmàcia Avda. Joan XXIII s/n 08028 Barcelona Spain, mbonfill@ub.edu,
Emir, A.
Ege University Department of Pharmacognosy, Faculty of Pharmacy 35100 Bornova, Izmir Turke,
Cicek-Polat, D.
Ege University Department of Pharmacognosy, Faculty of Pharmacy 35100 Bornova, Izmir Turke,
Kaya, G. I.
Ege University Department of Pharmacognosy, Faculty of Pharmacy 35100 Bornova, Izmir Turke,
Sarikaya, B.
Ege University Department of Pharmacognosy, Faculty of Pharmacy 35100 Bornova, Izmir Turke,
Onur, M. A.
Ege University Department of Pharmacognosy, Faculty of Pharmacy 35100 Bornova, Izmir Turke,
Unver-Somer, N.
Ege University Department of Pharmacognosy, Faculty of Pharmacy 35100 Bornova, Izmir Turke,
Knaś, M.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Szeremeta, D.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Polański, J.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Sajewicz, M.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland,
Kowalska, T.
University of Silesia Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland, teresa.kowalska@us.edu.pl,
Abstrakty : In many publications on the thin-layer chromatographic analysis of the medicinal plant extracts, striking skewness of the separated chromatographic bands with many phytochemicals can be seen, although no attention has ever been paid to this odd mass transfer effect. In our earlier studies on the thin-layer chromatographic enantioseparation of certain low molecular weight carboxylic acids, lateral relocation thereof (i.e., the side-wise deviation of their migration route from linearity) was registered. Then we found out that lateral relocation was observed with these analytes only, which structurally resembled molecular rotors. In this study, we investigate the role played by the thin-layer chromatographic stationary phases in lateral relocation of botanically relevant molecular rotors. Thus, three carboxylic acids were selected as the test analytes, all of them resembling molecular rotors and abundantly present in the medicinal plant extracts. We selected two most popular thin-layer chromatographic stationary phases also, i.e., silica gel (characterizing with microcrystalline chirality) and alumina (achiral). Lateral relocation of the test analytes was observed on the silica gel stationary phase only. A conclusion was drawn that the chiral stationary phase makes a complementary contribution to lateral relocation (along with the propeller-like molecular structure of the analytes). In our view, specially devised thin-layer chromatographic systems can prove a convenient nano-platform for future investigation of the drug transport patterns, advantageous in the pharmacokinetic studies.

Słowa kluczowe : molecular rotors, chirality, mass transfer in TLC, “asymmetric receptors” model, pharmacokinetics,
Wydawnictwo : University of Silesia in Katowice
Rocznik : 2013
Numer : Vol. 25, no. 4
Strony : 765 – 776
Bibliografia : 1 P. Pachaly and A. Koch, DC-Atlas Dünnschichtchromatographie in der Apotheke, Wissenschaftliche Verlagsgesellschaft Stuttgart, Stuttgart, 2012
2 Wagner and S. Bladt, Plant Drug Analysis, A Thin Layer Chromatography Atlas, 2nd Edition, Springer Verlag, Heidelberg, 2009
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DOI :
Cytuj : Patil, A. N. ,Nirmal, S. A. ,Chavan, A. K. ,Zhou, L. ,Xu, J. ,Luan, L. ,Ma, J. ,Gong, Y. ,Qin, D. ,Pan, C. ,Jinlong, M. ,Guobin, J. ,Bo, J. ,Hua, J. ,Montejo, C. ,Civera, C. ,Barcia, E. ,Negro, S. ,Fernández-Carballido, A. ,Czauderna, M. ,Marounek, M. ,Duskova, D. ,Kowalczyk, J. ,Konda, R. K. ,Chandu, B. R. ,Challa, B. R. ,Chandrasekhar, K. B. ,Shen, Y. ,Yang, H. ,Xia, G. ,Wang, J. ,Cai, B. ,Jia, X. ,Nurulain, S. M. ,Kalász, H. ,Szegi, P. ,Kuca, K. ,Adem, A. ,Hasan, M. Y. B. ,Hashemi, F. ,Tekes, K. ,Sangoi, M. S. ,Wrasse-Sangoi, M. ,Hurtado, F. K. ,Rolim, C. M. B. ,Walorczyk, S. ,Li, W. ,Shi, L. L. ,Han, L. Q. ,Zhang, J. ,Mirjalili, M. H. ,Navarro, A. ,Hernández, L. ,Jáuregui, O. ,Bonfill, M. ,Emir, A. ,Cicek-Polat, D. ,Kaya, G. I. ,Sarikaya, B. ,Onur, M. A. ,Unver-Somer, N. ,Knaś, M. ,Szeremeta, D. ,Polański, J. ,Sajewicz, M. ,Kowalska, T. , Specific mobility of selected phytochemicals in thin-layer chromatographic systems and its possible relevance to pharmacokinetics. Acta Chromatographica Vol. 25, no. 4/2013
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